ROLE OF ONCOGENE AND TUMOR SUPRESSOR GNEIN CHEMICALINDUCED MURINE BLADDER CARCINOMA

1993 Fiscal Year Final Research Report Summary

• Project/Area Number: 04670951
• Research Category: Grant-in-Aid for General Scientific Research (C)
• Allocation Type: Single-year Grants
• Research Field: Urology
• Research Institution: THA UNIVERSITY OF TOKYO
• Principal Investigator: HORIE Shigeo INSTRUCTOR,FACULTY OF MEDICINE,University of Tokyo, 医学部(病), 助手 (40190243)
• Project Period (FY): 1992 – 1993
• Keywords: Azatyrosine / ras oncogene / bladder cancer / BBN

Research Abstract

BBN is known to cause superficial bladder cancer in a rat, while, in a mouse, invasive bladder cancer is induced. The celluar mechanisms which cause this difference in tumor progression remained to be elucidated. We looked at the effect of Azatyrosine, which is known to intervene the activity of ras oncogene, on the inhibition of BBN-induced tumor progression. In rats, azatyrosine has no inhibitory effect of the progression of superficial bladder cancer. In mice, significantly less invasive and low grade tumors were observed in azatyrosine administered ones. Also in human cultured bladder cancer cell lines, azatyrosine showed growth inhibition. As a conclusion, azatyrosine has an inhibitory effect on the progression of invasive bladder cancer. This also might implies that intracellular ras activity plays important role in bladder oncogenesis.