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1994 Fiscal Year Final Research Report Summary

The regulation of the fetal growth-Assesment of feto-placental circulation and fetal growth promoting activity in the human fetus-

Research Project

Project/Area Number 04671006
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

MAEDA Hirotaka  School of Health Science, Kyushu University Associate Professor, 医療技術短期大学部, 助教授 (20199631)

Co-Investigator(Kenkyū-buntansha) TSUKIMORI Kiyomi  Department of Medicine Assistant, 医学部, 助手 (90253450)
SATOH Shoji  Department of Medicine Assistant, 医学部, 助手 (00225947)
KOYANAGI Takashi  Department of Medicine Associate Professor, 医学部, 助教授 (30136452)
Project Period (FY) 1992 – 1994
KeywordsHuman Fetus / Intrauterine growth retardation / Feto-placental circulation / Cell biology / Ultrasound velocimetry / Histopathology / Endothelial cell
Research Abstract

We studied the findings to changes in the feto-placental circualtion in normal and growth retarded fetuses (IUGR). Using pulsed Doppler methodology, it was revealed that placental vascular resistance was elevated in cases of IUGR and of decreased cerebral vascular resistance in some cases. When the fetal hypoxia is superimposed, RI values in the middle cerebral artery decrease, suggesting a protective, compensatory mechanism designed to increase the blood supply to the fetal brain. From biological examination of endothelial cells in IUGR fetuses with normotensive and hypertensive women, it was evident that the serum factor cytotoxic to endothelial cell is present in cases with preeclampsia, whereas the serum growth inhibitory factor is present in cases with normotensive women. On the basis of these findings, it is suggested that 1) one of the factor which regulate fetal growth is the pathological changes in the feto-placental circulation, 2) the endothelial cell function contribute to the mechanisms which change vascular resistance in the feto-placental circulation in the human fetus.

  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] H.Maeda,T.Koyanagi,H.Nakano.: "Intrauterine treatment on non-immune hydrops fetalis" Early Hum.Dev.29. 241-249 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Tsukimori,H.Maeda,M.Shingu,T.Koyanagi,M.Nobunaga,H.Nakano.: "The possible role of endothelial cells in hypertensive disorders during pregnancy." Obstet.Gynecol.80. 229-233 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Tsukimori,H.Maeda,K.Ishida,H.Nagata,T.Koyanagi,H.Nakano.: "The superoxide generation neutrophils in normal and preeclamptic pregnancies." Obstet.Gynecol.81. 536-540 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Maeda,H.Nagata,K.Tsukimori,S.Satoh,T.Koyanagi,H.Nakano.: "Prenatal evaluation and obstetrical management of fetuses at risk of developing lung hypoplasia." J.Perinat.Med.21. 355-361 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Tsukimori,H.Maeda,M.Shingu,T.Koyanagi,M.Nobunaga,H.Nakano.: "Possible mechanism of vascular damage in pre-eclampsia." J.Hum.Hypertension.8. 177-180 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Sakai,T.Imaizumi,H.Maeda,H.Nagata,K.Tukimori,A.Takeshita,H.Nakano.: "Venous distensibility during pregnancy Comparisons between normal pregnancy and preeclampsia." Hypertension. 24. 461-466 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Maeda, T.Koyanagi、H.Nakano: "Intrauterine treatment on non-immune hydrops fetalis." Early Hum.Dev.29. 241-249 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Sakai, H.Maeda, K.Tsukimori, H.Nagata, T.Koyanagi, H.Nakano: "How blood viscosity influences changes in circulation during pregnancy?" Fukuoka Acta Med.83. 328-332 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Tsukimori, H,Maeda, M.Shingu, T.Koyanagi, M.Nobunaga, H.Nakano: "The possible role of endothelial cells in hypertensive disorders during pregnancy." Obstet.Gynecol.80. 229-233 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Tsukimori, H.Maeda, K.Ishida, H.Nagata, T.Koyanagi, H.Nakano: "The superoxide generation of neutrophils in normal and preeclamptic pregnancies." Obstet.Gynecol.81. 536-540 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Maeda, H.Nagata, K.Tsukimori, S.Satoh, T.Koyanagi, H.Nakano: "Prenatal evaluation and obstetrical management of fetuses at risk of developing lung hypoplasia." J.Perinat.Med.21. 355-361 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Tsukimori, H.Maeda, M.Shingu, T.Koyanagi, M.Nobunaga, H.Nakano.: "Possible mechanism of vascular damage in pre-eclampsia." J.Hum.Hypertension. 8. 177-180 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Sakai, T.Imaizumi, H.Maeda, H.Nagata, K.Tsukimori, A.Takeshita, H.Nakano: "Venous distensibility during pregnancy-Comparisons between normal pregnancy and preeclampsia." Hypertension. 24. 461-466 (1994)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1996-04-15  

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