1994 Fiscal Year Final Research Report Summary
Effect of hormones on carcinogenesis of cervical cancer.
| Project/Area Number |
04671010
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Saga Medial School |
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Principal Investigator |
SUGIMORI Hajime Saga Medical School, Faculty of Medicine, Professor, 医学部, 教授 (50038642)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUO Norihito 佐賀医科大学, 医学部, 助手 (30244015)
YOKOYAMA Matashi Saga Medical School, Faculty of Medicine, Assistant, 医学部, 助手 (40230669)
FUKUDA Kouichi Saga Medical School, Faculty of Medicine, Lecturer, 医学部, 講師 (80189943)
IWASAKA Tsuyoshi Saga Medical School, Faculty of Medicine, Assistant Professor, 医学部, 助教授 (60117067)
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| Project Period (FY) |
1992 – 1994
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| Keywords | Cervical cancer / Oncogene / Hormone |
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| Research Abstract |
The importance of infection of human papilloma virus (HPV) was clarified by clinical and in vitro investigations. Not only in squamous cell carcinoma but also in adenocarcinoma HPV was noted in high frequency. Abnormal suppressor oncogene p53 was observed in HPV negative cancer cell lines, while only wildtype p53 was detected in HPV positive cell lines. A new immortalized cell line was established by introducing HPV 18 to the secondly culture cells from the normal cervix. This cell lines derived from endocervical cells showed strong atypia and cytokeratin resembled to HeLa cells which was adenocarcinoma cell line. This cell line will be useful for studying the carcinogenesis of adenocarcinoma of the cervix. The patients with dysplasia were followed up. High risk HPV (type 16/18) was frequently detected in patients with age of 30-40s. Progressed cases were mainly observed in 40s. There were few cases of progression or regression in patients over 50 year-old. This fact clearly indicated that progres or regress of carcinogenesis of the cervical cancer was strongly influenced by sezual hormones.
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[Publications] Iwasaka, T,Oh-uchida, M., Matsuo, N., Yokoyama, M., Fukuda, K., Hara, K., Fukuyama, K., Hori, K.& Sugimori, H.: "Correlation between HPV positivity and state of the p53 gene in cervical carcinoma cell lines." Gynecol Oncol. 48. 104-109 (1993)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Matsuo, N., Iwasaka, T., Hayashi, Y., Hara, K., Mvula, M.& Sugimori, H.: "Polymerase chain reaction analysis of human papillomavirus in adenocarcinoma and adenosquamous carcinoma of the uterine cervix." Int J Gynecol Obstet. 41. 251-256 (1993)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Fukuda, K., Hachisuga, T., Nakamura, S., Matsuo, N., Iwasaka, T.& Sugimori, H.: "Local immune response in persistent cervical dysplasia." Obstet Gynecol. 82. 941-945 (1993)
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「研究成果報告書概要(欧文)」より
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[Publications] Iwasaka, T., Yokoyama, M., Matsuo, N., Fukuda, K., Mvula, M.& Sugimori, H.: "Insitu hybridization analysis of human papillomavirus DNA in cervical intraepithelial neoplasia. Prospective follow-up study." The Cervix l.f.g.t.12. 55-60 (1994)
Description
「研究成果報告書概要(欧文)」より
