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1994 Fiscal Year Final Research Report Summary

Effect of hormones on carcinogenesis of cervical cancer.

Research Project

Project/Area Number 04671010
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionSaga Medial School

Principal Investigator

SUGIMORI Hajime  Saga Medical School, Faculty of Medicine, Professor, 医学部, 教授 (50038642)

Co-Investigator(Kenkyū-buntansha) MATSUO Norihito  佐賀医科大学, 医学部, 助手 (30244015)
YOKOYAMA Matashi  Saga Medical School, Faculty of Medicine, Assistant, 医学部, 助手 (40230669)
FUKUDA Kouichi  Saga Medical School, Faculty of Medicine, Lecturer, 医学部, 講師 (80189943)
IWASAKA Tsuyoshi  Saga Medical School, Faculty of Medicine, Assistant Professor, 医学部, 助教授 (60117067)
Project Period (FY) 1992 – 1994
KeywordsCervical cancer / Oncogene / Hormone
Research Abstract

The importance of infection of human papilloma virus (HPV) was clarified by clinical and in vitro investigations. Not only in squamous cell carcinoma but also in adenocarcinoma HPV was noted in high frequency. Abnormal suppressor oncogene p53 was observed in HPV negative cancer cell lines, while only wildtype p53 was detected in HPV positive cell lines. A new immortalized cell line was established by introducing HPV 18 to the secondly culture cells from the normal cervix. This cell lines derived from endocervical cells showed strong atypia and cytokeratin resembled to HeLa cells which was adenocarcinoma cell line. This cell line will be useful for studying the carcinogenesis of adenocarcinoma of the cervix. The patients with dysplasia were followed up. High risk HPV (type 16/18) was frequently detected in patients with age of 30-40s. Progressed cases were mainly observed in 40s. There were few cases of progression or regression in patients over 50 year-old. This fact clearly indicated that progres or regress of carcinogenesis of the cervical cancer was strongly influenced by sezual hormones.

  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Sugimori, H.& Iwasaka, T.: "Colposcopic appearances of the columnar epithelium." The Cervix lfgt. 10. 153-155 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwasaka, T,Oh-uchida, M., Matsuo, N., Yokoyama, M., Fukuda, K., Hara, K., Fukuyama, K., Hori, K.& Sugimori, H.: "Correlation between HPV positivity and state of the p53 gene in cervical carcinoma cell lines." Gynecol Oncol. 48. 104-109 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuo, N., Iwasaka, T., Hayashi, Y., Hara, K., Mvula, M.& Sugimori, H.: "Polymerase chain reaction analysis of human papillomavirus in adenocarcinoma and adenosquamous carcinoma of the uterine cervix." Int J Gynecol Obstet. 41. 251-256 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwasaka, T., Yokoyama, M., Hayashi, Y.& Sugimori, H.: "Human papillomavirus 16 and 18 DNA can solely induce oncogenic transformation of mammalian cells in primary culture." Acta Obstet Gynecol Scand. 72. 81-86 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukuda, K., Hachisuga, T., Nakamura, S., Matsuo, N., Iwasaka, T.& Sugimori, H.: "Local immune response in persistent cervical dysplasia." Obstet Gynecol. 82. 941-945 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sugimori, H.& Iwasaka, T.: "Cervical microcarcinoma : differential diagnosis." Arch STD/HIV Res. 8. 155-167 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yokoyama, M., Tsutumi, K., Pater, A.& Pater, M.: "Human papillomavirus 18-immortalized endocervical cells with in vitro cytokeratin expression characteristics of adenocarcinoma." Obstet Gynecol. 83. 197-204 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwasaka, T., Yokoyama, M., Matsuo, N., Fukuda, K., Mvula, M.& Sugimori, H.: "Insitu hybridization analysis of human papillomavirus DNA in cervical intraepithelial neoplasia. Prospective follow-up study." The Cervix l.f.g.t.12. 55-60 (1994)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1996-04-15  

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