1994 Fiscal Year Final Research Report Summary
Study on antihyperlipidemic action of an estrogen derivative ; 2-Methoxyestrogen.
| Project/Area Number |
04671012
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Univ. of the Ryukyus. |
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Principal Investigator |
KONO Shinzo Univ. of the Ryukyus. the faculty of Med. Prof., 医学部, 教授 (40041347)
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| Co-Investigator(Kenkyū-buntansha) |
OSHIRO Yoshihede Univ. of the Ryukyus. the faculty of Med. Assistant, 医学部, 助手 (60194148)
SUNAGAWA Yoko Univ. of the Ryukyus. the faculty of Med. Lecturer, 医学部, 講師 (00196908)
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| Project Period (FY) |
1992 – 1994
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| Keywords | Antihyperlipidemic action / Estrogens / 2-Methoxyestrogen |
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| Research Abstract |
The aim of this study is to clarify and antihyperlipidemic action of estrogens. The study comprises of following two items.
I.In dietary hypercholesterolemic and oophorectomized rats, Estradiol-17beta (E_2-17 beta) and 2-Methoxyestriol (2-MeOE_3) were administered, and the determinations of serum cholesterol and morphological observations of various organs were performed. Results were obtained as follows,
1) A remerkable hypercholesterolemic action was observed by the administration of E_2-17beta or 2-MeOE_3.
2) A decrease of wet weight was observed only in liver by the administration of E_2-17beta or 2-MeOE_3.
3) On microscapical findings, a fat deposit in liver was desreased by the administration of E_2-17 beta or 2-MeOE_3. The fat deposit decreased around the central vein in comprison with the area around grissons sheath. While fat deposited diffusely in liver of the non-hormone trated control group.
4) Endometrial hypertrophy of uterus was observed by the E_2-17 beta administration, but not by the 2-MeOE_3 administration.
II.In rats Otsuka Long-Evans Tokushima strain, fatty rats which were induced a hypercholesterolemic status with a hyperlipid diet. E_2-17 beta or 2-MeOE_3 administarated, and follwing results were obtained.
1) The serum cholesterol level was decreased by the administaration of E_2-17 beta or 2-MeOE_3.
2)The serum triglyceride level was decreased by the 2-MeOE_3 administaration.
3)The serum HDL-cholesterol level was increased by the 2-MeOE_3 administaration.
From these results, it was clarified that both E_2-17 beta or 2-MeOE_3 might have the antihyperlipidemic effects both in Wister and heriditary diabetic strain rats. Particularly, 2-MeOE_3 which has not the action to genetal organs might be expected to be developed for an antihyperlipidemic drug.
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