1994 Fiscal Year Final Research Report Summary
Injuries of biological membranes cauledby radicalcused in the dental vesin system and its prevention
| Project/Area Number |
04671180
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
補綴理工系歯学
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
FUJISAWA Seiichiro TOKYO MED.& DENT.UNV.ASSOCIATE PROFESSOR, 歯学部, 助教授 (40014162)
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| Co-Investigator(Kenkyū-buntansha) |
KOMODA Yasuo TOKYO MED.& DENT.UNV.PROFESSOR, 医用器材研究所, 教授 (60012639)
KADOMA Yoshinori TOKYO MED.& DENT.UNV.PROFESSOR10DA02 : 60012639, 医用器材研究所, 助教授 (00092403)
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| Project Period (FY) |
1992 – 1994
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| Keywords | Bentoyl peroxide / Polymenzation of wotheylweloerlate / Induction periode / radical scaverzing / Initial rate of polipenzation / antioxidants / Vitamin E / beta-carotene |
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| Research Abstract |
Benzoyl peroxide (BPO) is widely used as initiator of MMA polymerization of prosthetic devices. Peroxide radicals induced by BPO may cause the damage of oral mucosa due to lipid peroxidation of biological membranes. Antioxidants such as vitamin E,beta-carotene etc. act as radical scavengers. In this experiments, DSC polymerization was carried out in the presence of vitamin E,vitamin A,and beta-carotene which are mixed in MMA at various concentration . When the concentration of vitamin E increased, induction periode (IP) increased, whereas initial rate of poly merization (IRP) decreased. On the other hand, vitamin A did not change in both IP and IRP at high concentration. beta-carotene inhibited the polymerization of MMA at 0.5 mole%.
alpha-tocopherol (chain breaking) and beta-carotene (radical trapping) showed strong radical scavenging effect.
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