1993 Fiscal Year Final Research Report Summary
SYNTHETIC STUDY OF IONOPHORETIC SPHINGOGLYCOLIPID
Project/Area Number |
04671294
|
Research Category |
Grant-in-Aid for General Scientific Research (C)
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Allocation Type | Single-year Grants |
Research Field |
Chemical pharmacy
|
Research Institution | FUKUYAMA UNIVERSITY |
Principal Investigator |
SHIBUYA Hirotaka FUKUYAMA UNIVERSITY, FACULTY OF PHARMACY AND PHARMACEUTICAL SCIENCES, PROFESSOR, 薬学部, 教授 (50116042)
|
Co-Investigator(Kenkyū-buntansha) |
KITAGAWA Isao OSAKA UNIVERSITY, FACULTY OF PHARMACEUTICAL SCIENCE, PROFESSOR, 薬学部, 教授 (20028830)
|
Project Period (FY) |
1992 – 1993
|
Keywords | complex lipid / sphingoglycolipid / ion-transport activity / ionophoretic activity / soya-cerebroside / biological membrane |
Research Abstract |
In this research project, we have developed a new synthetic method for optically active sphingoglycolipids. glycerophospholipids, and glyceroglycolipids, employing a synthetic Synthon, chiral C4-epoxide, which were prepared from (2Z)-2-butene-1, 4-diol. By use of the method, we have synthesized a palmitoyl analogue of Gaucher spleen glucocerebroside, C16-platelet activating factor (C16-PAF), and a palmitoyl analogue of M-5 which is a biologically active glyceroglycolipid isolated from an Okinawan marine sponge. Furthermore, we have synthesized several analogues of soya-cerebroside II, a Ca^<++>-ionophoretic sphingoglycolipid isolated from soybean. In order to clarify the relationship between the ionophoretic activity of soya-cerebroside II and the stereostructure, we have next examined Ca^<++>-ionophoretic activities of the analogues using the apparatus W-08 and the human erythrocyte method, which were developed by us. As a result, it has been found that the presence of the 8Z-double bond, the 2'R-hydroxyl group, and the 4"S-hydroxyl group is necessary for soya-cerebroside II to show the Ca^<++>-ionophoretic activty.
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Research Products
(6 results)