1993 Fiscal Year Final Research Report Summary
PERCUTANEOUS ABSORPTION OF PEPTIDE DRUGS AND THE APPLICATION FOR MEDICAL TREATMENT
| Project/Area Number |
04671380
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | KINKI UNIVERSITY |
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Principal Investigator |
OGISO Taro KINKI UNIVERSITY, FAC PHARM.SCI., PROFESSOR, 薬学部, 教授 (60082971)
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| Co-Investigator(Kenkyū-buntansha) |
TANINO Tadatoshi KINKI UNIVERSITY, FAC.PHARM.SCI., ASSISTANT, 薬学部, 助手 (90236703)
IWAKI Masahiro KINKI UNIVERSITY, FAC.PHARM.SCI., LECTURER, 薬学部, 講師 (30140346)
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| Project Period (FY) |
1992 – 1993
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| Keywords | elcatonin / ebiratide / peptide percutaneous absorption / osteoporosis / absorption enhancement |
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| Research Abstract |
1. Improvement on Percutaneous Absorption of Elcatonin
When taurocholate and D-limonen were used together as enhancers, the percutaneous absorption of elcatonin (EC) was extensively enhanced and a high bioavailability (8.7%) was obtained.
2. Effectiveness of EC Transdermal System for the Treatment of Osteoporosis
The EC transdermal system and EC plus 1,25(OH)_2D_3 system, applied to the rat abdominal skin 6 time for 48 h, significantly increased the ash weight and calcium content of the tibia in the morbid rats, compared with those of placebo group (p <0.05). Thus, the EC systems were concluded to be an efficient drug delivery system for Paget's disease and osteoporosis.
3. Percutaneous Absorption of Ebiratide
The skin penetration of [^<125>I] ebiratide from gel formulation was the greatest when EDTA, n-octyl-beta-D-thioglucoside (OTG, 1.5%) and taurocholate (1.0%) or OTG and taurocholate were used together. When the transdermal systems were applied to rat abdomen, the plasma levels of radioactivity were much higher than those after control system without enhancers. These results clearly demonstrated that ebiratide was effectively absorbed through rat skin in the persence of enhancers.
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