1993 Fiscal Year Final Research Report Summary
Role of Carnitine on Lipid and Carbohydrate Metagolism
| Project/Area Number |
04671476
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
内分泌・代謝学
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| Research Institution | Osaka University |
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Principal Investigator |
KUWAJIMA Masamichi Osaka University, Internal Medicine, Assistant Professor, 医学部, 講師 (00205262)
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| Co-Investigator(Kenkyū-buntansha) |
KAWATA Sumio Osaka University, Internal Medicine, Assistant Professor, 医学部, 講師 (90183285)
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| Project Period (FY) |
1992 – 1993
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| Keywords | carnitine / cardiomegaly / mitochondria / long chain fatty acid / mit DNA / fatty liver / heart failure / carnitine transport activity |
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| Research Abstract |
To evaluate the role of carnitine on lipid and carbohydrate metabolism, we analyzed the metabolic disorders in congenital systemic carnitine deficient mouse (jvs mouse). Results are as follows ;
1. In an experiment to assay the uptake of carnitine using kidney slice, homozygous mutants showed significantly lower rates of Na-dependent carnitine uptake than controls. This results indicate that the primary defect of jvs mice is most probably related to the system for reabsorption of carnitine in the kidney.
2. Jvs mice show cardiac hypertrophy which is caused by enlargement of the cardiac muscle cell associated with enlargement of mitochondria. Carnitine administration significantly suppresses the cardiac hypertrophy. These results show that carnitine deficiency plays an important role in the development of the cardiac hypertrophy.
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[Publications] A.Otsuka, H.Katsura, M.Nanba, A.Ono, K.Yamamoto, T.Hanafusa, M.Kuwajima, N.Watanabe, N.Kono, S.Tarui: "Is microalbuminuria a sensitive indicator for systemic microangiopathy in NIDDM?" Prevention and Therapy of NIDDM, Y.Goto et al. eds., Smith-Gordon Pub.307-310 (1992)
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[Publications] H.Nakajima, T.Hamaguchi, K.Tomita, R.Uenaka, K.Yamagata, T.Hanafusa, M.Kuwajima, T.Noguchi, T.Tanaka, N.Kono, Y.Matsuzawa: "An alternate nonisotopic technique of PCR-mediated allele-specific oligonucleotide analysis for the detection of a point mutation" Res. Commun. Chem. Pathol PHarmacol.79(1). 3-10 (1993)
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[Publications] K.Yamagata, T.Hanafusa, H.Nakajima, T.Sato, T.Noguchi, K.Tomita, K.Tsuji, N.Kono, T.Tanaka, S.Tarui, M.Kuwajima, H.Inoko and Y.Matsuzawa: "Overepression of HLA class I antigen reduces insulin secretion in pancreatic beta cells (Rinm5F) : Evidence for a non-immune mechanism" Res. Commn. Chem. Pathol Pharmacol.81(3). 299-308 (1993)
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[Publications] M.Horiuchi, H.Yoshida, K.Kobayashi, K.Kuriwaki, K.Yoshimine, M.Tomomura, T.Koizumi, H.Nikaido, J.Hayakawa, M.Kuwajima, T.Saheki: "Cardiac hypertrophy in juvenile visceral steatosis (jvs) mice with systemic carnitine deficienty" FEBS Lett.326 (1, 2, 3). 267-271 (1993)
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