1993 Fiscal Year Final Research Report Summary
DEVELOPMENT OF NEW FUNCTIONALIZED HOST MOLECULES VIA HIGH PRESSURE REACTION
| Project/Area Number |
04804037
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
有機化学一般
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| Research Institution | OKAYAMA UNIVERSITY |
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Principal Investigator |
TSUKUBE Hiroshi OKAYAMA UNIVERSITY, COLLEGE OF LIBERAL ARTS & SCIENCE, ASSOCIATE PROFESSOR, 教養部, 助教授 (00144725)
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| Project Period (FY) |
1992 – 1993
|
| Keywords | HIGH PRESSURE / HOST-GUEST CHEMISTRY / CROWN ETHER / LIQUID MEMBRANE TRANSPORT |
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| Research Abstract |
High-pressure S_NAr reaction was first applied to the synthesis of a new family of macrocyclic host molecules, which incorporated various heteroaromatics as potential cation binding sites in a unique fashion. In CH_2Cl_2 liquid membrane transport experiments, several macrocycles having thiazole, oxazole, pyrazine and pyridazine rings exhibited a perfect Ag^+ ion selectivity. Cation extraction and ^<13>C NMR titration experiments revealed that attachment of unique heterocycle to the parent macro-ring, if in the proper position, significantly offered excellent Ag^+ ion specificity. Since binding and transport selectivities of these macrocycles were apparently higher than those with conventional crown ethers, the present study provided a useful method for synthesis of a new, specific host molecule.
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