1993 Fiscal Year Final Research Report Summary
Immunohistochemical and molecular biological analysis of neuronal migration
| Project/Area Number |
04807005
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Gunma University (1993)
Keio University (1992) |
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Principal Investigator |
SHIRAO Tomoki Gunma Univ. Sch. Med. Dept. Neurobiol & Behave. Professor, 医学部, 教授 (20171043)
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHI Kensuke Gunma Univ. Sch. Med. Dept. Neurobiol & Behave. Assistant Professor, 医学部, 助手 (50218567)
KOBAYASHI Satoshi Keio Univ, Sch. Med. Dept. Physiol. Instructor, 医学部, 助手
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| Project Period (FY) |
1992 – 1993
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| Keywords | drebrin / neural development / cell migration / cytoskeleton / actin / actin-binding-protein / ***** / ***** |
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| Research Abstract |
Drebrins are developmentally regulated brain proteins which were first isolated from chick embryonic brain. Immunochemical analysis has revealed that they are concentrated in submembraneous regions of neurons, and the embryonic form of drebrin is pouportedly concerned with neuronal migration during development. In this study we immunohistochemically analyzed the expression of drebrin, embryonic N-CAM, SVP38, GFAP and vementin within the migrating subependymal cells, which are considered to be the postmitotic precursors of granule cells in the rat olfactory bulb, or to be glial progenitor cells. Some of the cells, which attached to one another, expressed drebrin and embryonic N-CAM.These immunoreactive cells made a stream from the anterior horn of lateral ventrice to the olfactory bulb. Since glial cells do not express drebrin, these immunoreactive cells are thought to be migrating neuroblasts.
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