1993 Fiscal Year Final Research Report Summary
A study of pathomechanism of drug/metal allergy by oral administration
Project/Area Number |
04807074
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Research Category |
Grant-in-Aid for General Scientific Research (C)
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Allocation Type | Single-year Grants |
Research Field |
Dermatology
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Research Institution | Yokohama City University |
Principal Investigator |
IKEZAWA Zenro Yokohama City University, School of Med., Dept.of Dermatol, Associated Professor, 医学部, 助教授 (90046128)
|
Co-Investigator(Kenkyū-buntansha) |
OSAWA Junko Yokohama City University, School of Med., Dept.of Dermatol, Instructor, 医学部, 助手
|
Project Period (FY) |
1992 – 1993
|
Keywords | amlexanox / oral tolerance / cross-reaction / piroxicam-thimerosal / piroxicam-tenoxicam / metal allergy / fluoressein / candida & adjuvant |
Research Abstract |
(1)Allergenicity and tolerogenicity of amlexanox(AMLX) were examined in guinea pigs. The results indicated that AMLX is not only a strong contact sensitizer but also a strong tolerogen. Therefore, it seems likely that a substantial reduction in the risk of AMLX sensitization by Elics(AMLX) opthalmic solution may be achieved by prior oral administration of Solfa(AMLX) tablets. (2)A cross-reaction between piroxicam(PXM)-photosensitivity and thimerosal(TMS)- and thiosalicylate(TOS)- hypersensitivity was revealed by in vivo skin testing and by in vitro lymphocyte proliferation test in guinea pigs, indicating that PXM photosensitivity in man is induced by contact senstization with TMS, and then is photoallergic in nature. Also it is suggested that the optimum proliferative response of the TOS-primed lymph node cells to PXM plus UVA needs peritoneal cells. Furthermore, PXM was revealed to have at least two distinct epitopes for contact photoallergy from a study of the cross-reaction/cross-desensitization to tenoxicam(TXM), as well as to TOS. (3)Patient with gold dermatitis due to ear piercing developed positive patch test reactions to both Au^<3+> and Hg^<2+>. A correlation between Au^<3+> and Hg^<2+> hypersensitivities was suggested from animal experiments. (4)Enhancing effects of fluorescein(F) on generalized rash induced by beta-lactam antibiotics and on PHA-P response of whole blood were observed in guinea pigs. Accordingly, it is likely that F playd a dominant role in the high incidence of new beta-lactam drug eruptions during the volunteer trials of phaseII. (5)Adjuvant-like effect of various allergens on anti-wheat IgG antibody response of Balb/c mice fed with wheat was evaluated. The results suggested that allergens such as candida albicans may act on development of wheat allergy as immunopotentiator.
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Research Products
(8 results)