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1994 Fiscal Year Final Research Report Summary

The effect of neural transplantation for spinal cord injury

Research Project

Project/Area Number 04807101
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionMie University

Principal Investigator

WAGA Shiro  Mie University Faculty of Medicine, Neurosurgery, Professor, 医学部, 教授 (50026861)

Co-Investigator(Kenkyū-buntansha) SHIMOSAKA Shinichi  Mie University Hospital, Neurosurgery, lecturer, 医学部・附属病院, 講師 (20162729)
KANAMARU Kenji  Mie University Hospital, Neurosurgery, lecturer, 医学部・附属病院, 講師 (70185908)
Project Period (FY) 1992 – 1994
KeywordsSpinal cord injury / Methylprednisolone / 21-aminosteroid / Astrocyte / Microglia
Research Abstract

It is well known that high-dose methylprednisolone sodium succinate (MPSS) and 21-aminosteroid U-74006F are effective in the treatment of experimental acute spinal cord injury but effect for the site away from the impact site is not known. We studied the effecacy of high-dose MPSS and U-74006F on nucleus gracilis in rats with Th8 spinal cord injury. MPSS was administered intravenously in dose of 30 mg/kg during a 15-minute period followed by 45-minute pause and then a 23-hour continuous infusion of 5.4 mg/kg. U-74006F was administered intravenously in dose of 1.5 mg/kg and then a 9-hour continuous infusion of 0.5 mg/kg. Control rats were treated with saline.
Three days postlesion, the rats were sacrificed and the brain section was stained immunocytochemically with glial fibrillary acidic protein (GFAP) and OX-42. GFAP and OX-42 immunoreactivity of the nucleus gracilis in MPSS group and U-74006F group were higher than that in the control group. Astrocytes and microglia have been known as the source of neurotrophic factors and play significant roles in neuroprotective and regenerative responses, so the high density of astrocytes and microglia reaction in the nucleus gracilis in the MPSS and U-74006F group may suggest neuroprotective and regeneartive effect on the remote site. MPSS and U-74006F may be effective on the distal site far away fromthe impact site.

  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Mizuno M,et al.: "Effects of high-dose methyl prednisolone sodium succinate therapy on remote glial activation in exporimantal sponal cord injury." J Neurotrauma. 12. 399 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mizuno M,et al.: "Effects of high-dose methyl prednisolone and 21-aminosteroid on remote glial activation in experimental acute spinal cord injury." Society for Nauroscience Abstracts. 21. 815 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mizuno M: "Effects of high-dose methyl prednisolone on glial activation in spinal cord injury." Mie Medical Journal. 46(in print). (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mizuno M,et al.: "Efficacy of the 21-avrinosteroid at the remote site of spinal cord injury." Aduances in Neurotrauma Deseurch. 7(in print). (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mizuno M,Shimosaka S,Waga S,Kojima T: "Effects of high-dose methylprednisolone sodium succinate theraoy on remote glial activation in experimental acute spinal cord injury." J Neurotrauma. 12. 399 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mizuno M,Shimosaka S,Tanaka K,Waga S,Kojima T,Kubo Y: "Effects of high-dose methylprednisolone and 21-aminosteroid on remote glial activation in expermental acute spinal cord injury." Society for Neuroscience Abstracts. 21. 815 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mizuno M: "Effects of high-dose methylprednisolone on glial activation in spinal cord injury." Mie Medical Journal. 46 (in print). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mizuno M,Shimosaka S,Waga S: "Efficacy of the 21-aminosteroid at the remote site of spinal cord injury." Advances in Neurotrauma Research. 7 (in print). (1995)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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