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1995 Fiscal Year Final Research Report Summary

Medical Scientific Research on Highlanders in Himalayas

Research Project

Project/Area Number 05041107
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionField Research
Research InstitutionChiba University

Principal Investigator

KURIYAMA Takayuki  School of Medicine. Chiba University Professor, 医学部, 教授 (20009723)

Co-Investigator(Kenkyū-buntansha) 肖 和平  チベット結核対策センター, 所長
SHRESTA G.P.  トリバン大学, 医学部, 教授
HAYANO Masashi  School of Medicine. Chiba University Lecturer, 医学部, 助手 (10272329)
ONOZAKI Ikushi  Anti-Tuberculosis Association, 研究員
KOBAYASHI Toshio  Tokyo University of Mercantile Marine Sub-Professor, 助教授 (20251069)
KIMURA Hiroshi  School of Medicine. Chiba University Sub-Professor, 医学部, 講師 (20195374)
TANAKA Michiko  Jyunshin Women College Sub-Professor, 講師 (30249700)
MASUDA Atsuko  School of Medicine. Chiba University Sub-Professor, 医学部, 助手 (70165710)
MASUYAMA Shigeru  School of Medicine. Chiba University Lecture, 医学部, 助手 (00219354)
FUKUDA Yasuichirou  School of Medicine. Chiba University Professor, 医学部, 教授 (10009649)
KOHNO Toshihiko  Kokusai Budo University Professor, 教授 (50092052)
SAKAKIBARA Yoshikazu  Kanazawa Institute Technology Professor, 教授 (50092060)
NOGAWA Kouji  School of Medicine. Chiba University Professor, 医学部, 教授 (40019584)
MIKATA Atsuo  School of Medicine. Chiba University Professor, 医学部, 教授 (40051289)
G.P Shresta  Tribuban University Hospital Professor
XIAO He-Ping  Tibet Tuberculosis Control Center Director
Project Period (FY) 1993 – 1995
KeywordsHypoxia / High Altitude / Adaptation / Tuberculosis / Hodgkin Disease / EB virus / Gastric cancer / Lymphoma / Helicobacter pylori
Research Abstract

1. Respirato-physiological study in Nepal Himalayan. Study of altitude acclimatization mechanism of respiratory control was carried out in Nepal Khumbu area. Resting ventilation and SpO2s during breath holding test from end-expiratory lung volume and effect of oxygen on these parameters were studied at 1300m, 2827m, 3440m and 4430m. Analysis of relationships between these parameters and hypoxic ventilaotry response revealed that even after acclimatizing period increased hypoxic chemosensitivity was accompanied by hypoxic ventilatory depression which was markedly detected in acute hypobaric hypoxia study at sea level.
2. Pathological study on EB virus related tumors in Nepal. Regional differences have been reported in a histological type of Hodgkin disease (HD) and frequency of EB virus related HD.24 cases of lymphoma and 54 cases of gastric cancer speciemens of the pathological department of Tribuban University Hospital and CMN Patan Hospital in Katmandu were studied immunologically and pathologically. 7 out of 8 HD and 1 out of 16 non-Hodgkin lymphoma cases revealed LMP-1 and EBER-1 ISH positive. In case of gastric cancer, only one out of 54 cases was a positive. Helicobacter Pylori infection was identified in 14 cases out of 38 low differentiated type and one case out of 2 mucous type. No case was positive in 13 high and intermediate differentiated types.
3. Histological study on high-altitude animals. Histological study on alveolar structure of Yak (Bos grunnieens) grown up in Nepal Himalayan region and Tibetan plateau was performed. Optical microscopic study showed that the Yak have wider alveolar space and thinner alveolar wall, though elastic fibers in the wall were more clearly identified than that of human. Electron microscopic study showed fewer type II alveolar endothelial cell and more and larger Kohn's pores than rat. These modified configuration in alveolar structure is considered to be morphological adaptive response to long term hypoxia.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] 河野俊彦・三方敦男 栗山喬之: "ヤクの肺の組織学的構造に関する所見" 登山医学. 15. 129-134 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Masuyama,T.Kuriyama et.al.: "Preserved vagal tone and fractal property in HR variance in Sherpa" Hypoxia and the Brain. Eds.by R.Sutton. Queen City Printers Inc,Varmont. 330 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Masuyama,T.Kuriyama et.al.: "Camparison of Respiratory and Circrlatary interuction during progrssice hypoxia and acute hypobaric hypoxia" Respiratory and Critical Care Medicine. 153(4). (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 三方淳男・増山茂 栗山喬之他: "ネパール王国におけるEBV関連腫瘍" 日本病理学会雑誌. (in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小林敏生.増山茂: "低地居住者の高所低酸素環境下における呼吸調節機能の適応" 日本衛生学雑誌. (in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 増山茂 栗山喬之他: "低酸素換気応答は息こらえの決定因子となるか?" 日本胸部疾患学会雑誌. vol 340. 256 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Honda,A Masuda,T.Kobayashi,M.Tanaka,H Kimura,S.Masuyama T.Kuriyama: "Proceedings of the London Conference on Modeiliy and control of ventilation" Plenam Press, (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 増山 茂: "中高年のための登山学" 日本放送出版協会, 159 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Kohono, A.Mikata and T.Kuriyama: "A histological study on the respiratory organ of Yak." Japanese Journal of Mountain Medicine. 15. 129-133 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Masuyama, Y.Honda, T.Kuriyama et al.: "Preserved vagal tone and fractal property in HR variance in Sherpa" "Hypoxia and Brain" eds. By Sutton et al. Queen Printers Inc., Vermont. 330 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] A.Mizoo, S.Masuyama, T.Kuriyama et al.: "Comparison of Respiratory and Circulatory interaction during progressive hypoxia and acute hypobaric hypoxia." Respiratory and Critical Care Medicine. 154 (4). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] A.Mikata, T.Kuriyama, S.Masuyama et al.: "EBV related tumors in Nepal" Japanese Journal of Pathology. (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Kobayashi and S.Masuyama: "Altitude acclimatization of respiratory functions in lowlanders" Japanese journal of Hygiene. 51 (1). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Honda, A.Masuda, T.Kobayashi, M.Tanaka, S.Masuyama and T.Kuriyama: "Individual difference in ventilation and HR responses to progressive hypoxia following 100% O2 exposure in humans" Proceeding of the London Conference on modeling and control of ventilation. (1995)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1997-03-04  

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