• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1994 Fiscal Year Final Research Report Summary

The role of stress protein-reactive gammadeltaT cells in infection

Research Project

Project/Area Number 05044178
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionJoint Research
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

MATSUZAKI Goro  Dept.Immunol., Med.Inst.Bioreg., Kyushu Univ. Assistant Professor, 生体防御医学研究所, 助手 (30229455)

Co-Investigator(Kenkyū-buntansha) IVANYI Juraj  Medical Research Council, Tuberculosis and Related Infections Unit, Professor, 教授
Project Period (FY) 1993 – 1994
KeywordsgammadeltaT cells / stress protein / bacterial infection
Research Abstract

We have reported that gammadeltaT cells reactive to stress protein increase at early stage of Listeriainfection. We also found that stress protein-reactive gammadeltaT cells increase in syngeneic mixed lymphocyte reaction (MLR). From the observations, we estimated that self stress protein/bacterial stress protein-cross reactive gammadeltaT cells increase after bacterial infection. Therefore we analyzed self-reactive gammadeltaT cells to know further characteristics of stress protein-reactive gammadeltaT cells.
We establisher 8 self-reactive gammadeltaT cell hybridomas. Four hybridomas expressed Vdelta5 and four hybridomas expressed Vdelta6. Response of seven out of eight self-reactive gammadeltaT cell hybridomas was blocked by anti stress protein (Hsp60) -monoclonal antibody ML30. Since response of gammadeltaT cell hybridomas with different T cell receptor was blocked with the ML30 antibody, we reasoned that Hsp60 molecule, but not ML30 epitope of Hsp60, participate in antigen recognition by the gammadeltaT cell hybridomas.

  • Research Products

    (2 results)

All Other

All Publications (2 results)

  • [Publications] Ivanyi,I.,Norton,P.,and Matsuzaki,G.: "Stress Proteins in Medicine" (in press), (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ivanyi, J., Norton, P., and Matsuzaki, G.: (in press). Stress Proteins and Medicine, (1995)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1996-04-15  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi