1996 Fiscal Year Final Research Report Summary
Asymmetric Total Synthesis of Chiral Molecules
| Project/Area Number |
05234102
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Research Institution | Okayama University of Science (1994-1995)
Hokkaido University (1993) |
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Principal Investigator |
YONEMITSU Osamu Okayama University of Science, Faculty of Science, Professor, 理学部, 教授 (60001038)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Kiyoyuki Nagoya University, Graduate School of Science, Professor, 大学院・理学研究科, 教授 (90022540)
MORI Kenji Science University of Tokyo, Faculty of Science, Professor, 理学部, 教授 (20011843)
HASHIMOTO Shun-ichi Hokkaido University, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (80107391)
TAKAHASHI Takashi Tokyo Institute of Technology, Faculty of Engineering, Professor, 工学部, 教授 (80110724)
HIRAMA Masahiro Tohoku University, Graduate School of Science, Professor, 大学院・理学研究科, 教授 (30165203)
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| Project Period (FY) |
1993 – 1995
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| Keywords | asymmetric total synthesis / organic natural product / optically active chiral compound / selective reaction / biologically active compound / multi-step synthesis / condensation reaction / protecting group |
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| Research Abstract |
Asymmetric synthesis of complex chiral compounds such as useful natural products is one of important purposes of modern synthetic chemistry. This project "asymmetric total synthesis of chiral molecules" was carried out by about 20 synthetic chemists for three years beginning in 1993. Target molecules of this project, divided in four groups, are not only structurally complex compounds with many chiral centers and functional groups but also quite useful compounds with important biological activities and new functions : 1) Regulatory compounds of biological functions. 2) Chemical signal compounds. 3) Pharmacologically and physiologically active compounds. 4) Biologically active natural products produced in ultramicroquantity. During three years, we obtained many noteworthy results such as new synthetic methods of prostacyclines and prostaglandins, asymmetric synthesis and absolute configuration determination of various pheromons, computer-aided synthesis of enediyn compounds, hapten synthesis of ciguatoxin, synthesis of the crucial intermediate of taxol, asymmetric synthesis of tetracyclins, total synthesis of antitumor aplyronine A,lactone-ring synthesis of tedanolide, and total synthesis of hygrolidin.
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