1997 Fiscal Year Final Research Report Summary
"Man-Earth System : A scientific approach to realize human society in harmony with the Earth"-Future Advanced Living Environment and Its Possible Effects on Humans-
| Project/Area Number |
05278113
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Research Institution | Kyoto University |
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Principal Investigator |
IKENAGA Mitsuo Kyoto University, Radiation Biology Center, Professor, 放射線生物研究センター, 教授 (70025378)
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| Co-Investigator(Kenkyū-buntansha) |
NIWA Ohtsura Kyoto University, Radiation Biology Center, Professor, 放射線生物研究センター, 教授 (80093293)
MORIMOTO Kanehisa Osaka University, Faculty of Medicine, Professor, 医学部, 教授 (20143414)
TAKAHASHI Senmtaro Radiation Medical Center, Comparative Environmental Effects Research Group, Group Leader, 比較環境影響研究グループ, 研究室長 (60163268)
YOSHIKAWA Isao Nagasaki University, Faculty of Environmental Studies, Associate Professor, 環境科学部, 助教授 (80039528)
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| Project Period (FY) |
1993 – 1997
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| Keywords | Advanced Living Environment / Human Health Effects / Underground Air Pollution / Oxidative DNA Damage / Space Environment / In Vitro Transformation / Genomic Instability / Magnetic Field |
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| Research Abstract |
The objective of this research group is to study possible health effects of advanced living conditions in the 21th century, such as living in underground cities or in space environment, by using appropriate model systems. The results revealed that : (i)suspended particulated matters in air of Tokyo subway stations contained more Fe and Cr elements than those of above ground, and were more cytotoxic to cultured macrophages, (ii) asbestos induced oxidative DNA damage and polynuclear human cells, (iii) RBE of heavy ions for induction of transformation showed a maximum value (6.3) at LET of 100 keV/μ, (iv) irradiated sperm caused maternal allele mutations in mouse as well as Drosophila, an evidence of radiation-induced genomic instability, and (v) timevarying magnetic Held induced somatic mutations in Drosophila.
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Research Products
(2 results)
