1997 Fiscal Year Final Research Report Summary
"Man-Earth System : A scientific approach to realize human society in harmony with the Earth"-Genetic Determinants Affecting Sensitivity to Environmental Factors-
| Project/Area Number |
05278118
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Research Institution | Kitasato University |
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Principal Investigator |
IMURA Nobumasa Kitasato University, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (70012606)
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| Co-Investigator(Kenkyū-buntansha) |
ICHIHASHI Masamitsu Kobe University, Faculty of Medicine, Professor, 医学部, 教授 (00030867)
UTSUMI Hideo Kyushu University, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (20101694)
KAMATAKI Tetsuya Hokkaido University, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (00009177)
KUDO Ichiro Showa University, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (30134612)
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| Project Period (FY) |
1993 – 1997
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| Keywords | Toxicity of Heavy metals / Species Difference / Drug Metabolism / Genetic Polymorphism / Ultraviolet Radiation B / Skin Cancer Risk Factor / Oxidative Stress / Antioxidative Enzymes |
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| Research Abstract |
The objectives of this research are to identify genetic determinants affecting the sensitivity of individuals to environmental factors and to study the implication of polymorphisms in determination of the sensitivity by utilizing gene technology and biochemical techniques. The following genetic factors were identified as modifying factors for environmental hazards, and biochemical mechanisms for the polymorphism were investigated. The intestinal handling of Cd by metallothionein for Cd accumulation in the kidney, a new type of mutation in cytpchrome P450 2D6 (CYP2D6) gene for the metabolic activation of procarcinogen in cigarette smoke, antioxidative enzymes for the toxicity of 2, 4, 6-trichlorophenol (TCP), outdoors work, skin type I, seborrheic keratosis, and severe sunburn in childhood for the risk of normelanoma skin cancers, and phospholipase A2 depletion for the risk of colon cancer.
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Research Products
(2 results)
