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1995 Fiscal Year Final Research Report Summary

Integrated research on neurobehavioral methods and effects in occupational, environmental and community health.

Research Project

Project/Area Number 05404026
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Public health/Health science
Research InstitutionUniversity of Tokyo

Principal Investigator

ARAKI Shunichi  University of Tokyo, School of Medicine, Professor, 医学部(医), 教授 (00111493)

Co-Investigator(Kenkyū-buntansha) TANIGAWA Takeshi  University of Tokyo, School of Medicine, Instructor, 社会医学系, 講師 (80227214)
KAWAKAMI Norito  University of Tokyo, School of Medicine, Instructor, 医学部(医), 助教授 (90177650)
SATA Fumihiro  University of Tokyo, School of Medicine, Instructor, 医学部(医), 助手 (90187154)
MURATA Katsuyuki  University of Tokyo, School of Medicine, Instructor, 医学部(医), 助手 (80157776)
YOKOYAMA Kazuhito  University of Tokyo, School of Medicine, Associate Professor, 医学部(医), 助教授 (00158370)
Project Period (FY) 1993 – 1995
KeywordsOccupational health / Environmental health / Community health / Newrobehaviard effects / Neurobehaviard methods / neurobehaviaral test batlery / moleculer biology / Immnnological methods
Research Abstract

To develop our previous research including international collaboration and promote integrate researches, the following studies were conducted.
1.Various new neurophysiological methods and neurobehavioral test battery, which had been proved to be useful in our previous studies, were applied to examine the effects of wide variety of occupational end environmental factors, to clarify subclinical neurological, psychological and behavioral effects and establish their dose-effects relationship.
2.Immunological methods, which had been developed in our laboratory on human subjects, were applied to various neurotoxic disorders, occupational cancers, work-related diseases, neurological and psychiatric diseases, to clarify immunological and molecular changes underlying them and verify these methods.
3.The above data were compared with those obtained in USA,Denmark, China, etc, where we had conducted international collaborative works.
4.Cohort study was carried out on a group of children in Faroe islands, Denmark, whose histry of exposure to methyl mercury had been well known, to examine if they had subclinical neurobehavioral or neurophysiological changes.
5.Epidemiological studies using the above methods were performed in China and Indonesia, focusing environmental pollution, occupational diseases and traffic accidents.
6.Based on these data, preventive strategics for neurological, psychological and behavioral disorders due to occupational and environmental factors were discussed.

  • Research Products

    (50 results)

All Other

All Publications (50 results)

  • [Publications] Wang,X.,: "Dysphea and exercise testing in workers exposed to silica." Industrial Health. 33. 163-171 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Wang,X.,: "Effects of smoking on respiratory tunction and exercise performance in asbestos workers" Industril Health. 33. 173-180 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Imanaka,Y.,: "Patient judgement of the quality of ambulatory care In a Japanese setting." Clinical Performance and Quality Health Care. 3. 197-208 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sata,F.,: "Adjustment of creatinine-odjusted values in urine to urinary tlow rate : A study of eleven heavy metals and organic substances" International Archives of Occupational and Environ mental Health. 68. 64-68 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Morita,Y.,: "A reference value for delta-aminolevulinic acid in plasma in population occupationally uneyposed to lead." Industrial Health. 34. 57-60 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawakami,N.,: "Changes in rates of dpressive symptons in a Japanese working population : Life table analysis from a 4 year follow up study." Psychological Medicine. 25. 1181-1190 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Murata,K.,: "Subclinical impairment in the median nerve across the carpal tunnel among female VDT operators." International Archives of Occupational and Environmental Health. 68. 75-79 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sata,F.,: "Adjustment of creatinine-adjusted value to flow rate in rate in lead workers." Anchives of Environmental Health. 68. 64-68 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawakami,N.,: "Assessment of job stress dimensions based on the job demands-control model in employees of telecommunication and electric power companies in Japan" International Journal of Behavioral Medicine. 2. 358-375 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Murata,K.,: "Accumulation of VDT work-related visual fatigue assessed by visual evoked potential,near point distance and critical flicker fusion." Industrial Health. 34. 61-69 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 佐藤 元: "慢性関節リウマチ患者のQOLと患者の主観的健康感・生活満足度との関係について." 日本公衆衛生雑誌. 42. 743-754 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岡島 史佳: "エイズ(AIDS)患者の診療体制に関する研究-東京都エイズ研究班の病院調査より-" 日本公衆衛生雑誌. 42. 779-807 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 荒記俊一: "魚多食集団における有機水銀汚染-フェロ-諸島" 公衆衛生. 59. 321-324 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 荒記俊一: "環境因子による非顕性の神経・精神行動障害の評価と最近の知見." 日本衛生学雑誌. 50. 713-729 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 荒記俊一: "日本行動医学会(JSBM)の創立と初期の活動-国際行動医学会の流れより-" 行動医学研究. 2. 12-19 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 北村文彦: "産業保健と分子生物学-職業癌および環境癌へのアプローチ." 公衆衛生. 59. 851-854 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 荒記俊一: "産業神経中毒と精神生理学-ICOH,WHO,IPCS,ILO,ECなどの取組み." 公衆衛生. 60. 1-6 (1996)

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      「研究成果報告書概要(和文)」より
  • [Publications] 荒記俊一: "産業保健マニュアル(第3版)" 南山堂, 4 (1995)

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      「研究成果報告書概要(和文)」より
  • [Publications] 荒記俊一: "作業関連疾患予防マニュアル作成委員会報告書" 中央労働災害防止協会, 24 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 多田羅浩三: "公衆衛生資料集 NO.4." 日本公衆衛生協会, 156 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 多田羅浩三: "脳卒中発症者に対する地域ケアネットワークの確立" 日本公衆衛生協会, 13 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Murata, K.: "Subclinical impairment in the median nerve across the carpal tunnel among female VDT operators" Int Arch Occup Environ Health. 68. 75-79 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yuasa, J.: "Investigation on neurotoxicity of occupational exposure to cyclohexane : a neurophysiological study" occupational and environmental medicine. 53. 174-179 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yuasa, J.: "Study of urinary mandelic acid concentration and peripheral nerve conduction among stirene workers" American Journal of Industrial Medicine. 30. 41-47 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yokoyama, K.: "Subclinical vestibulo-cerebellar, anterior cerebellar lobe and spinocerebellar effects in lead workers in relation to concurrent and past exposure" Neuro Toxicology. 18(2). 371-380 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yokoyama, K.: "Postural sway frequency analysis in workers exposed to n-hexane, xylene, and toluene : assessment of subclinical cerebellar dysfunction" Environmental Research. 74. 110-115 (1997)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Murata, K.: "Effects of occupational use of vibrating tools in the autonomic, central and peripheral nervous system" Int Arch Occup Environ Health. 70. 94-100 (1997)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Murata, K.: "Asymptomatic sequelae to acute sarin poisoning in the central and autonomic nervous system 6 months after the Tokyo subway attack" J Neurol. 244. 601-606 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yokoyama, K.: "A preliminary study on delayd vestibulo-cerebellar effects of Tokyo subway sarin poisoning in relation to gender difference : frequency analysis of postural sway" JOEM. 40(1). 17-21 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kishi, R.: "Effects of prenatal exposure to stirene on the neurobehavioral development, activity, motor coordination and learning behavior of rats" Neurotoxicology and Teratology. 17(2). 121-130 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Eguchi, T.: "Impaired color discrimination among workers exposed to stirene : relevance of a urimary metabolite" Occupational and Environmental Medicine. 52. 534-538 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Aiba, I.: "Change in magnetic resonance imaging and clinical signs in a case of chronic toluene intoxication by sniffing" J Occup Health. 38. 13-19 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kondo, H.: "Toluene induces behavioral activation without affecting striatal dopamine metabolism in the rat : behavioral and microdialysis studies" Pharmacology Biochemistry and Behavior. 51(1). 97-101 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kamijima, M.: "Toxic effects of hexane derivatives on cultured rat Schwann cells" Toxicology. 108. 25-31 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuoka, M.: "Creatine kinase activities in brain and blood : possible neurotoxic indicator of acrylamide intoxication" Occupational and Environmental Medicine. 53. 468-471 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuoka, M.: "Induction of c-fos expression by tributyltin in PC12 cells : involvement of intracellular Ca2^+" Environmental Toxicology and Pharmacology. 2. 373-380 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yu, Z.: "Suppression of pentylenetetrazol-induced seizures by carnitine in mice" Naunyn-Schmiedeberg's Arch Pharmacol. 355. 545-549 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuoka, M.: "Induction of c-fos gene by mercury chloride in LLC-PK1 cells" Chemico-Biological Interactions. 108. 95-106 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawakami, N.: "Assessment of job stress dimensions based on the job Demands-Control model of employees of telecommunication and electric power companies in Japan : reliability and validity of the Japanese version of Job Content Questionnaire" International Journal of Behavioral Medicine. 2(4). 358-375 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawakami, N.: "Changes in rates of depressive symptoms in a Japanese working population : life-table analysis from a 4-year follow-up study" Psychological Medicine. 25. 1181-1190 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawakami, N.: "Prevalence of mood and anxiety disorders in a working population in Japan" JOEM. 38(9). 899-905 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawakami, N.: "Effects of job strain on helper-inducer and suppressor-inducer T cells in Japanese blue-collar workers" Psychother Psychosom. 66. 192-198 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawakami, N.: "Effects of work related stress reduction on depressive symptoms among Japanese blue-collar workers" Scand J Work Environ Health. 23. 54-59 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakata, A.: "Effects of Uncontrollable and controllable electric shocks on T lymphocyte subpopulations in the peripheral blood, spleen, and thymus of rats" Neuroimmunomodulation. 3. 336-341 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kobayashi, F.: "Changes in psychophysiological functions during night shift in nurses : influence of changing from a full-day to a half-day work shift before night duty" Int Arch Occup Environ Health. 69. 83-90 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murata, K.: "Assessment of autonomic neurotoxicity in occupational and environmental health as determined by ECG R-R interval variability : A review" American Journal of Industrial Medicine. 30. 155-163 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Araki, S.: "Neurophysiological methods in occupational and environmental health : Methodology and recent findings" Environmental Research. 73. 42-51 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Igisu, H.: "Protection of the brain by carnitine" J Occup Health. 37. 72-82 (1995)

    • Description
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  • [Publications] Araki, S.: "Biobehavioral approach in occupational, environmental and community health : a report based on fourteen-year studies" Journal of Epidemiology. 6(4). S79-S88 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kobayashi, F.: "Japanese perspective of future worklife" Scand J Work Environ Health. 23 Suppl 4. 66-72 (1997)

    • Description
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Published: 1999-03-16  

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