| Co-Investigator(Kenkyū-buntansha) |
TAKAYASU Tatsunori Kanazawa Univ., Faculty of Medicine, Legal Medicine, Assoc. Professor, 医学部, 助教授 (80154912)
YOSHITA Yutaka Kanazawa Univ., University Hospital, Intensive Care Unit, Instructor, 医学部・附属病院, 助手 (30201023)
OHSIMA Tohru Kanazawa Univ., Faculty of Medicine, Legal Medicine, Professor, 医学部, 教授 (40183024)
HASHIMOTO Takuma Kanazawa Univ., Faculty of Medicine, Laboratory Medicine, Professor, 医学部, 教授 (10124710)
NAGANO Taizo National Institute of Police Science, Head, 所長 (20073679)
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| Research Abstract |
The present research is composed of basic and practical studies. Furthermore, the basic study is divided into the following three subjects : 1. pharmacokinetic study, 2. study on quality control and 3. development of new analytical methods for drugs and poisons.
1. The mechanism of interindividual differences on drug action and toxicity was investigated by using physiological pharmacokinetic analyzes. Systematic approach to individualizing the dose was established. In order to predict the change during regeneration and recovery from hepatic damage, an altered AST was found to be a good index of metabolic function. Quantitative relationship between structure and peritoneal membrane transport for acidic drugs were also established. The potential effects of chemical drugs on the effects of biotechnological drugs were discovered.
2. IRMA,EIA and CLEIA methods were studied for LH,FSH,etc. in the plasma in a hospital laboratory. Based on the results obtained, the importance of quality control
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was concretely demonstrated.
3. (1) An analytical method for benzodiazepines was newly developed using supercritical fluid extraction and supercritical fluid chromatography. (2) The availability of rapid quantitative analytical system (REMEDi-HS) was basically examined. Practically, REMEDi-HS system was applied to the samples in emergency medical care and medico-legal autopsy cases, and the advantages and disadvantages of the system were discussed. (3) Pulse heating method was applied to the analysis of volatile substances including widely used anesthetics. (4) Even in the formalin-fixed tissues, methamphetamine, volatile substances, diazepam and chlorpromazine were determined by GC-MS.
In emergency medical care and medico-legal autopsy cases, blood and urine were analyzed by the screening system above. Among the emergency care cases, there was a case with successful diagnosis as an acute bromisovalum intoxication by the system, and the information much contributed to the specific therapy of the patient. In the autopsy cases, there were cases in which methamphetamine and barbital were determined in the lethal and therapeutic level, respectively. In such cases, drug analysis gives useful information to assess objective evidence on dead bodies. Less
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