1996 Fiscal Year Final Research Report Summary
Morphological and physiological studies of age-related changes in pulp and periodonata* tissues, and epidemiological study of atypical orofacial pai*.
| Project/Area Number |
05404065
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Conservative dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SUDA Hideaki Tokyo Medical and Dental University, Dentistry, Professor, 歯学部, 教授 (00114760)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Hideharu Tokyo Medical and Dental University, Dentistry, Research Associate, 歯学部, 助手 (20222896)
OKIJI Takashi Tokyo Medical and Dental University, Dentistry, Research Associate, 歯学部, 助手 (80204098)
SUNAKAWA Mitsuhiro Tokyo Medical and Dental University, Dentistry, Lecturer, 歯学部, 講師 (30179288)
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| Project Period (FY) |
1993 – 1996
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| Keywords | ageing / odontoblast / macrophage / plasma cell / microneurography / alkaline phosphatase / EMG activity / chemical stimulation |
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| Research Abstract |
Age-related changes were as follows : 1) These existed some differences in rat jaw muscle EMG activity induced by mustard oil application to maxillary tooth pulps ; the less EMG activities were evoked and the latency of late phase EMG response was prolonged in 20-week-old rats ; 2) OX6+cells increased in number after the eruption of the tooth. In aged rats, the density of ED1+cells was maintained but a significant decrease in the density of OX6+cells was observed ; 3) Percentage of nerve fibers hydrodynamically activated decreased in elderly subjects. While evoked and spontaneous discharges were observed, old subjects sometimes did not perceive any sensations ; 4) In human tooth pulp, alkaline phosphatase activity decreased with increasing age but cell cycle did not change.
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[Publications] Kawashima, N., Okiji, T., Ogawara, M., Kamal, A.M.M., Rungvechvuttivittaya, S., Sakurai, K., Suda, H.: "Dendritic Cell-specific Antigen-expressing Cells in Rat Pulpal and Periapical Tissues." Proceedings of the International Conference of "Influence on Dentin Permeability of Microbial Challenge to the Dentin/Pulp Complex. 323-324 (1996)
Description
「研究成果報告書概要(欧文)」より
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