• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1996 Fiscal Year Final Research Report Summary

Non-invasive measurements of sensory nerve and cortical responses to skin stimulation : Integration of EEG,MEG and fMRI

Research Project

Project/Area Number 05404087
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionTokyo Institute of Psychiatry

Principal Investigator

HASHIMOTO Isao  Tokyo Institute of Psychiatry Dept.of Psychophysiology, Head, 参事研究員 (40250211)

Co-Investigator(Kenkyū-buntansha) IMADA Toshiaki  NTT Basic Laboratory Group Leader, 基礎研究所, グループリーダー
Project Period (FY) 1993 – 1996
Keywordsmagnetoencephalography / electroencepholography / air-puff stimulation / vibratory stimulation / action fields / subcrtically generated fields / high-frequency oscillations (>300 Hz) / inhibitory interneurons
Research Abstract

1. We developed 3 point air-puff stimulators which can be controlled independently for eliciting sensory nerve action potentials and somatosensory evoked potentials.
2. We developed 3 point vibratory stimulators for studying somatosensory evoked fields associated with perception of frequency, duration and intensity in the somatosensory system.
3. We visualized displacements of the skin following air-puff stimulation with a high speed camera which were correlated with a sensory threshold and magnitude estimations.
4. We visualized a moving quadrupole along the median nerve with multi-chnnel measurements of action fields over the elbow.
5. In peripheral nerve lesions, we found a peculiar oscillation pattern of electrically evoked action fields at or distal to the lesion sites. We performed a computer simulation for the oscillation using the Hodgikin-Huxley equations and found that the increase of Na conductance was related to the oscillation.
6. We measured magnetic fields following trigemina … More l stimulation from the decorticated piglets and showed that the subcortically generated fields are strong enough to the detectable outside the head.
7. We measured N20m primary response during wakefulness and sleep with subsequent digital high-pass (>300 Hz) and low-pass (>300 Hz) filtering. The estimated source for the high-frequency oscillations (HFOs) was the area 3b very close to that for the N20m. During sleep, the HFOs showed a dramatic diminution in amplitude while the N20m amplitude exhibited a moderate increment. This reciprocal relation between the HFOs and the N20m during a wake-sleep cycle suggests that they represent opposing generator substrates. We speculate that the HFOs represent a localized activity of the GABAergic inhibitory interneurons of layr 4, which have been shown in animal experiments to respond monosynaptically to thalamo-cortical input with a high-frequency (600-900 Hz) burst of short duration spikes. On the other hand, the underlying N20m represents activity of pyramidal neurons which receive monosynaptic excitatory input from the thalamus as well as a feed-forward inhibition from the interneurons. This hypothesis has been further supported by our recent experiments manipulating the amplitude of N20m during wakefulness ; the reciprocal relation between HFOs and N20m hold not only during a wake-sleep cycle but also during wakefulness. Less

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] 橋本 勲: "Disparity between sensory nerveactivity and psychophysical responses for air-puff stimulation of the index finger and palm in man" Neurol. Res.16. 63-67 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 橋本 勲: "Visualization of a moving quadrupoie with magnetic measurements of peripheral nerve action fields" Electroenceph. clin. Neurophysiol.93. 459-467 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 橋本 勲: "Multichannel detection of magnetic compound action fields with stimulation of the index and little fingers" Electroenceph. clin. Neurophysiol.97. 102-113 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 橋本 勲: "Perceptual changes accompanyingcontrolled blocking of cutaneous afferents are related to somatosensory evoked potentials" Neurol. Res.17. 24-32 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 橋本 勲: "Neuronal activities from a deepsubcortical structure can be detected magnetically outside the brain in the porcine preparation" Neurosci. Lett. 206. 25-28 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 橋本 勲: "Somatic evoked high-frequency oscillations reflect activity of inhibitory interneurons in the human somatosensory cortex" Electroenceph. clin. Neurophysiiol.100. 189-203 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 橋本 勲: "Supplement 47 to Electroenceph. clin. Neurophysiol. Elsevier" Visualization of Informtion Processing in the Human Brain : Recent Advances in MEG and Functional MRI, (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] I.Hashimoto, K.Yoshikawa, M.Sasaki, T.Gatayama, M.Nomura, S.Yokoyama and K.Sano: "Disparity between sensory nerve activity and psychophysical responses for air-puff stimulation of the index finger and palm in man." Neurol.Res.16. 63-67 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] I.Hashimoto, T.Masahiko, T.Mizuta, T.Imada, Y.Iwase and H.Okazaki: "Visualization of a moving quadrupole with magnetic measurements of peripheral nerve action fields." Electroenceph.clin.Neurophysiol.93. 459-467 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] I.Hashimoto, T.Masahiko, T.Mizuta, T.Imada, Y.Iwase, H.Okazaki and K.Yoshikawa: "Multichannel detection of magnetic compound action fields with stimulation of the index and little fingers." Electroenceph.clin.Neurophysiol.97. 102-113 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] I.Hashimoto, K.Yoshikawa, T.Gatayama, M.Sasaki, M.Nomura, S.Yokoyama and K.Sano: "Perceptual changes accompanying controlled blocking of cutaneous afferents are related to somatosensory evoked potentials." Neurol.Res.17. 24-32 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] I.Hashimoto, N.Papuashvili, C.Xu and Y.C.Okada: "Neuronal activities from a deep subcortical structure can be detected magnetically outside the brain in the porcine preparation." Neurosci.Lett.206. 25-28 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] I.Hashimoto, T.Mashiko and T.Imada: "Somatic evoked high-frequency oscillations reflect activity of inhibitory interneurons in the human somatosensory cortex." Electroenceph.clin.Neurophysiol.100. 189-203 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] I.Hashimoto, Y.C.Okada and S.Ogawa: Visualization of Information Processing in the Human Brain : Recent Advances in MEG and Functional MRI.Supplement 47 to Electroenceph.Clin.Neurophysiol.Elsevier Science, Amsterdam, (1996)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1999-03-16  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi