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1994 Fiscal Year Final Research Report Summary

Functional Design of Glycopolymers and Synthetic Polymers Carrying Biological Ricognition Signals

Research Project

Project/Area Number 05453145
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 高分子合成
Research InstitutionNagoya University

Principal Investigator

KOBAYASHI Kazukiyo  Nagoya University, Faculty of Agriculture, Associate Professor, 農学部, 助教授 (10023483)

Co-Investigator(Kenkyū-buntansha) OKADA Masahiko  Nagoya University Faculty of Agriculture, Professor, 農学部, 教授 (20023103)
Project Period (FY) 1993 – 1994
KeywordsSynthetic Polysaccharides / Glycopolymers / Dynamic Aspects of Natural Products Chemistry / Enzyme-Catalyzed Synthesis / Fluorinated Polysaccharides / Fine Structure Recognition / Biomimetic Materials / Glycotechnology
Research Abstract

Well-defined glycopolymers and synthetic polysaccharides having carbohydrate recognition signals have been synthesized.
(1) A convenient synthetic methodology via N-glycosidation has been developed to introduce biologically important, complex oligosaccharides. Amino function was introduced to the reducing terminal of N,N'-diacetylchitobiose and lactose with ammonium hydrogen carbonate and then allowed to react with rho-vinylbenzoyl chloride. Homo- and copolymerizations of rho-vinylbenzamide-beta-oligosaccharide monomers with acrylamide were carried out with azobisisobutyronitrile as initiator in dimethyl sulfoxide at 60 ゚C.
(2) Artificial glycopeptides were prepared by one-pot reaction of N,N'-diacetyl-chitobiosyl amine and lactosyl amine with the side chain carboxyl groups of polyglutaminic acid in the presence of peptide condensation reagents.
(3) Graft copolymers consiting of synthetic polymer backbone and polysaccharide grafts have been synthesized by phosphorylase-catalyzed synthesis of amylose-substituted stirene derivative and its polymerization.
(4) Regiospefcifically fluorinated stereoregular polysaccharides, 3-deoxy-3-fluoro- (1*6) -alpha-D-glucopyranan was synthesized via ring-opening polymerization of anhydro sugar derivative.

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] A.Kobayashi: "Receptor-Mediated Regulation of Differentiation and Proliferation of Hepatocytes by Synthetic Polymer Model of Asialoglycoprotein" J.Biomatrials Sci.,Polymer Edn.(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小林明: "細胞接着システムの新展開" 化学と生物. 32. 260-268 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] A.Kobayashi: "Chemo-enzymatic Synthesis of a Glycopolymer Carrying Clustered-N-acetyl-β-lactosamine Moieties" J.Carbohydr.Chem.13. 753-766 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Matsushita: "Induction of Cytochrome P-450s and Expression of Liver-specific Genes in Rat Primary Hepatocytes Cultured on Different Extracelluar Matrices" Biosci.Biotech.Biochem.58. 1514-1516 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小林一清: "人工複合糖質高分子:生物認識能をもつ生体機能材料を目指した展開" 油化学協会誌「分子認識特集号」. 43. 960-967 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小林一清: "新タンパク質応用工学" フジテクノシステム, 印刷中

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Kobayashi: "Neoglycocojugates:Preparation and Application" Academic Press, 23 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 赤池敏宏: "別冊日経サイエンス 糖鎖と細胞" 日経サイエンス社, 16 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Kobayashi: "Methods in Enzymology,Vol.242,Neoglycoconjugates,Part A,Synthesis" Academic Press, 10 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Kobayashi: "Methods in Enzymology,Vol.247,Neoglycoconjugates,Part B,Biomedical Applications" Academic Press, 10 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] A.Kobayashi: "Receptor-Mediated Regulation of Diffrentiation of Hapatocytes by Synthetic Polymer Model of Asialoglycoprotein" J.Biomaterials Sci., Polymer Edn.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Kobayashi: "Chemo-enzymatic Synthesis of a Glycopolymer Carrying Clustered-N-acetyl-lactosamine Moieties" J.Carbohydr.Chem.13. 753-766 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Matsushita: "Induction of Cytochrome p-450s and Expression of Liver-Specific Genes in Rat Primary Hepatocytes Cultured on Different Extracellular Matrices" Biosci.Biotech.Biochem.58. 1514-1516 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Kobayashi: Neoglycoconjugates : Preparation and Applications. (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Kobayashi: Methods in Enzymology, Vol.242, Neoglycoconjugates, Part A,Synthesis. (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Kobayashi: Methods in Enzymology, Vol.247, Neoglycoconjugates, Part B,Biomedical Appplications. (1994)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1996-04-15  

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