• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1995 Fiscal Year Final Research Report Summary

Signal Transduction and Control of T-cell function by Prolactin

Research Project

Project/Area Number 05453176
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field General medical chemistry
Research InstitutionMie University

Principal Investigator

NAKASHIMA Kunio  Mie University Faculty of Medicine, Professor, 医学部, 教授 (40022800)

Co-Investigator(Kenkyū-buntansha) HOSOKAWA Yoshitaka  Mie Univ.Faculty of Medicine, Assistant, 医学部, 助手 (60229193)
TANAKA Minoru  Mie Univ.Faculty of Medicine, Associate Professor, 医学部, 助教授 (90024736)
Project Period (FY) 1993 – 1995
KeywordsRat / Nb2 lymphoma cell / G1 cyclin / Cyclin D2 / Cyclin D3 / Gene expression / Promoter / Prolactin
Research Abstract

Prolactin has been demonstrated to induce the expression of the genes encoding cyclin D2 and D3 during promotion of the G1/S transition in rat Nb2 pre-T lymphoma cells. cDNA clones encoding these rat cyclins D2 and D3 were isolated and sequenced. The genes for cyclin E,cdk2, cdk5 and E2F-1 are also expressed synergistically at the same stage, suggesting the presence of a common cellular mechanism to stimulate these genes. It has also been found that, during the same G1/S transition phase, prolactin stimulates TCR-nu gene expression in 4 h and represses TCR-alpha and beta genes in the Nb2 cells. These results suggest that prolactin participates in the regulation of mammalian T-cell differentiation and proliferation.

  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Yoshitaka Hosokawa,他: "Prolactin induces switching of T-cell receptor gene expression from α to γ in rat Nb2 pre-T lymphoma cells" Biochem.Biophys.Res.Commun.(印刷中). (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshitaka Hosokawa,他: "Symergistic gene expression of cyclin E,cdk2,cdk5 and E2F during the prolactin-induced G1/S transition in rat Nb2 pre-T lymphoma cells" Biochem.Mol.Biol.Internatinal. 37. 393-399 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takahiko Fujikawa,他: "Restraint stress enhances the gene expression of prolactin yeceptor long form at the choroia plexus" Endocrinology. 136. 5608-5613 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshitaka Hosokawa, Tadafumi Onga and Kunio Nakashima: "Induction of D2 and D3 cyclin-encoding genes during promotion of the G1/S transition by prolactin in rat Nb2 cells." Gene. 147. 249-252 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshitaka Hosokawa, Miao Yang, Stoshi Kaneko and Kunio Nakashima: "Synergistic gene expressions of cyclin E,cdk2, cdk5 and E2F-1 during the prolactin-induced G1/S transition in rat Nb2 pre-T lymphoma cells." Biochem.Mol.Biol.Int.37(2). 393-399 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takashi Fujikawa, Hideaki Soya, Hideo Yoshizato, Kesami Sakaguchi, Katsumi Doh-ura, Minoru Tanaka and Kunio Nakashima: "Restraint stress enhaces the gene expression of prolactin receptor long form at the choroid plexus." Endocrinology. 136(12). 5608-5613 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kesami Sakaguchi, Minoru Tanaka, Takeshi Ohkubo, Katsumi Doh-ura, Takahiko Fujikawa, Shu Sudo and Kunio Nakashima: "Induction of brain prolactin receptor long form mRNA expression and maternal behavior in the pup-contacted male rats : Promotion by prolactin administration and suppression by female contact." Neuroendocrinology. (in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshitaka Hosokawa, Miao Yang, Satoshi Kaneko, Minoru Tanaka and Kunio Nakashima: "Prolactin induces switching of T-cell receptor gene expression from alpha to nu in rat Nb2 pre-T lymphoma cells." Biochem.Biophys.Res.Commun.(in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1997-03-04  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi