1994 Fiscal Year Final Research Report Summary

Research for Inhibitors to Marine Organisms That Give Damages to Aqaculture

Research Project

Project/Area Number	05453205
Research Category	Grant-in-Aid for General Scientific Research (B)
Allocation Type	Single-year Grants
Research Field	Bioorganic chemistry
Research Institution	THE UNIVERSITY OF TOKUSHIMA
Principal Investigator	KUSUMI Takenori UNIVERSITY OF TOKYSHIMA,FACULTY OF PHARMACEUTICAL SCIENCES,PROFESSOR, 薬学部, 教授 (70015882)
Co-Investigator(Kenkyū-buntansha)	OHNO Nobuo SUMITOMO CHEMIGA INDUSTRY,CHIEF RESEARCHER, 宝塚総合研究所, 主席研究員
Project Period (FY)	1993 – 1994
Keywords	Natural Product / pearl-oyster / allelopathic substances / insecticide / alga / marine invertebrate / Polydore / aquaculture
Research Abstract	A tiny marine invertebrate, Polydora, give serious damages to Japanese aquaculture, especially to cutivated pearl-oyster and scallop. Chemical components of marine organisms which inhibit Polydora have been search for. After establishing a good bioassay system using larval Polydora, we have found that the brown alga, Dictyota dichotoma, contains extremely active compouds. After separation by use of chromatographic methods, crenulacetal C has been isolated as the most active compoud : It kills larval Polydora at 1 ppm during 3 h. On the basis of the chemical structure of crenulacetal C,simpler compounds have been synthesized. A compound having a nonyl side chain has been found to be as active as the nautralproduct.

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