1994 Fiscal Year Annual Research Report

ミトコンドリアDNAからみた現生人類の起源

Research Project

Project/Area Number	05454005
Research Institution	NATIONAL INSTITUTE OF GENETICS
Principal Investigator	宝来聰国立遺伝学研究所, 総合遺伝研究系, 助教授 (40126157)
Keywords	ミトコンドリアDNA / ヒト上科 / 塩基配列 / 分子時計 / ヒトの起源
Research Abstract	ヒト上科におけるミトコンドリアDNA(mtDNA)の塩基置換速度と分岐年代をより正確に推定するため、3人のヒト(アフリカ人、ヨーロッパ人、日本人)と3種のアフリカ類人猿(チンパンジー、ピグミーチンパンジー、ゴリラ)とオランウータンの全塩基配列を解析した。時間に対してほぼ直線的に蓄積している塩基置換を用いると、オランウータンとアフリカ類人猿は1,300万年前に分岐したという化石での推定年代のもとでは、ヒトとチンパンジーが490万年前に分岐したという結果が得られた。この分岐年代に基づいて、同義置換速度を推定したところ、3.89×10^<-8>/座位/年という値が得られた。Dループ領域における置換速度に関しては、7.00×10^<-8>/座位/年の値を得た。同義置換とDループ領域の置換の両方を用いることにより、ヒトmtDNAの最後の共通祖先の年代は143,000±18,000年前と推定した。アフリカ人の塩基配列が最も多様であるということと、上のヒトのntDNAの起源の年代より、現生人類ホモサピエンスのアフリカ起源説が強く支持された。

Research Products

(14 results)

All Other

All Publications (14 results)

[Publications] Umetsu K. et al.: "Polymorphisms of complement component I and ClR subcomponent of Cl in nine aboriginal Taiwanese populations." Human Biology. 66(2). 339-348 (1994)
[Publications] Kadowaki T.et al.: "A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA." New Eng.J.Med.330. 963-968 (1994)
[Publications] Kawakami Y.et al.: "Mitochondrial myopathy with progressive decrease in mitochondrial tRNA^<Leu(UUR)> mutant genomes." Ann.Neurol.35. 370-373 (1994)
[Publications] Marie S.K.N.et al.: "A Caucasian family with 3271 mutation in mitochondrial DNA." Biochem.Med.Metabol.Biol.52. 136-139 (1994)
[Publications] Hattori Y.et al.: "Point mutations in mitochondrial tRNA genes:sequence analysis of chronic progressive external ophthalmoplegia(CPEO)." J.Neurol.Sci.125. 50-55 (1994)
[Publications] Goto Y.et al.: "A new point mutation at nucleotide pair 3291 of the mitochondrial tRNA^<Leu(UUR)> gene in a patient with MELAS." Biochem.Biophy.Res.Commun.202(3). 1624-1630 (1994)
[Publications] Murakami T.,et al.: "Enzymatic and genetic adaptation of soleus muscle mitochondria to physical training in rats." Am.J.Physiol.267. 388-395 (1994)
[Publications] Horai S.et al.: "Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs." Proc.Natl.Acad.Sci.USA,. 92. 532-536 (1995)
[Publications] Umetsu K.,et al.: "Orsomucoid phenotyping with monoclonal antibodies:Polymorphic occurrence of ORMl^*Q^o in Aboriginal Taiwanese populations." Hum.Hered. (in press). (1995)
[Publications] Hammer M.& Horai S.: "Y chromosomal DNA variation and the peopling of Japan." Am.J.Hum.Genet.(in press). (1995)
[Publications] Jin F.et al.: "Genetic polymorphism of ADA in Taiwan aboriginal populations:New ADAv ariants detected by isoelectric focusing method." Antropological Science. (in press). (1995)
[Publications] Hayashi S.et al.: "Molecular phylogeny of gibbons inferred from mitochondrial DNA sequences." J.Mol.Evol.(in press). (1995)
[Publications] Horai S.: "The origin and past of Homo sapiens sapiens as viewed from DNA.S.Brenner and K.Hanihara(eds.)," World Scientific Publishing (in press), (1995)
[Publications] Horai S.et al.: "Prehistoric dispersal of Mongoloids.T.Akazawa(ed.)" Oxford University Press (in press), (1995)

1994 Fiscal Year Annual Research Report

ミトコンドリアDNAからみた現生人類の起源

Principal Investigator

宝来 聰 国立遺伝学研究所, 総合遺伝研究系, 助教授 (40126157)

Research Products

[Publications] Umetsu K. et al.: "Polymorphisms of complement component I and ClR subcomponent of Cl in nine aboriginal Taiwanese populations." Human Biology. 66(2). 339-348 (1994)

[Publications] Kadowaki T.et al.: "A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA." New Eng.J.Med.330. 963-968 (1994)

[Publications] Kawakami Y.et al.: "Mitochondrial myopathy with progressive decrease in mitochondrial tRNA^<Leu(UUR)> mutant genomes." Ann.Neurol.35. 370-373 (1994)

[Publications] Marie S.K.N.et al.: "A Caucasian family with 3271 mutation in mitochondrial DNA." Biochem.Med.Metabol.Biol.52. 136-139 (1994)

[Publications] Hattori Y.et al.: "Point mutations in mitochondrial tRNA genes:sequence analysis of chronic progressive external ophthalmoplegia(CPEO)." J.Neurol.Sci.125. 50-55 (1994)

[Publications] Goto Y.et al.: "A new point mutation at nucleotide pair 3291 of the mitochondrial tRNA^<Leu(UUR)> gene in a patient with MELAS." Biochem.Biophy.Res.Commun.202(3). 1624-1630 (1994)

[Publications] Murakami T.,et al.: "Enzymatic and genetic adaptation of soleus muscle mitochondria to physical training in rats." Am.J.Physiol.267. 388-395 (1994)

[Publications] Horai S.et al.: "Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs." Proc.Natl.Acad.Sci.USA,. 92. 532-536 (1995)

[Publications] Umetsu K.,et al.: "Orsomucoid phenotyping with monoclonal antibodies:Polymorphic occurrence of ORMl^*Q^o in Aboriginal Taiwanese populations." Hum.Hered. (in press). (1995)

[Publications] Hammer M.& Horai S.: "Y chromosomal DNA variation and the peopling of Japan." Am.J.Hum.Genet.(in press). (1995)

[Publications] Jin F.et al.: "Genetic polymorphism of ADA in Taiwan aboriginal populations:New ADAv ariants detected by isoelectric focusing method." Antropological Science. (in press). (1995)

[Publications] Hayashi S.et al.: "Molecular phylogeny of gibbons inferred from mitochondrial DNA sequences." J.Mol.Evol.(in press). (1995)

[Publications] Horai S.: "The origin and past of Homo sapiens sapiens as viewed from DNA.S.Brenner and K.Hanihara(eds.)," World Scientific Publishing (in press), (1995)

[Publications] Horai S.et al.: "Prehistoric dispersal of Mongoloids.T.Akazawa(ed.)" Oxford University Press (in press), (1995)

宝来聰国立遺伝学研究所, 総合遺伝研究系, 助教授 (40126157)