1994 Fiscal Year Final Research Report Summary
Development of technetium-99m and rhenium-186 labeled monoclonal antibodies for imaging and therapy.
| Project/Area Number |
05454299
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Gunma University |
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Principal Investigator |
ENDO Keigo Gunma University School of Medicine Professor, 医学部, 教授 (10115800)
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| Project Period (FY) |
1993 – 1994
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| Keywords | Radionuclides / Diagnostic Imaging / Radionuclide Therapy / Monoclonal antibody / Technetium-99m / Rhenium-186 |
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| Research Abstract |
This study was performed to develop new imaging and therapeutic methods using technetium-99m and rhenium-186 labeled monoclonal antibodies.
Technetium-99m labeled antibodies against carcinoembryonic antigen (CEA) were intravenously administered to patients with colorectal cancer, and its biodistribution and tumor uptake were examined in 12 patients. Eleven (92%) cases showed positive results with antibodies and tumor-to-normal tissue ratios obtained with SPECT correlated well with those obtained using surgical specimen. The highest tumor-to-normal tissue ratio reached more than 14 and there were several cases who seemed to be good candidates for radioimmunotherapy. Techetium-99m labeled anti-CA125 antibodies also accumulated in the ovarian cancer tissues in 3 out of 7 cases and needs further investigation.
The biggest problem inherent to clinical use of monoclonal antibodies is the generation of human anti-murine antibody (HAMA) in the serum of patients who received monoclonal antibodies. Rapid progress of gene technology allowed us to produced humanized monoclonal antibodies. Technetium-99m labeled humanized antibodies were safely administered to patients and no HAMA were detectable in their serum. Clinical use of humanized antibodies seemed promising not only in the immunoscintigraphy but also in the therapy of cancer.
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[Publications] Inoue, T., Shigeta, M., Mochizuki, H., Shimizu, T., Morikawa, A., Suzuki, H., Watanabe, N., Tateno, M.Oriuchi, N., Hirano, T., Tomiyoshi, K.and Endo, K.: "Effect of inhaled furosemide on lung clearance of Technetium-99m-DTPA." J.Nucl.Med.36. 73-77 (1995)
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「研究成果報告書概要(欧文)」より
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[Publications] Hosono, M., Endo, K., Hosono, N.M., Kobayashi, H., Shirato, M., Sakahara, H., Ueda, R.and Konishi, J.: "Treatment of small-cell lung cancer zenografts with iodine-131-anti-neural cell adhesion of absorbed dose in tissue." J.Nucl.Med.35. 296-300 (1994)
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「研究成果報告書概要(欧文)」より
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[Publications] Kobayashi, H., Sakahara, H., Hosono, M., Yao, Z.S., Toyama, S., Endo, K., and Konishi, J.: "Improved clearance of radiolabeled biotinylated monoclonal antibody following the infusion of avidin as a "Chase" without decreased accumulation in the target tumor." J.nucl.Med.35. 1677-1684 (1994)
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「研究成果報告書概要(欧文)」より
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[Publications] Arano, Y., Matsushima, H., Tagawa, M., Inoue, T., Koizumi, M., Hosono, M., Sakahara, H., Endo, K., Konishi, J.and Yokoyama, A.: "A newly designed radioimmunoconjugate releasing a hippurate-like radiometal chelate for enhanced target/non-target radioactivity." Nucl.Med.Biol.21. 63-69 (1994)
Description
「研究成果報告書概要(欧文)」より
