1994 Fiscal Year Final Research Report Summary
DEVELOPMENT OF MONOCLONAL ANTIBODY-GUIDED SURGERY FOR CANCER PATIENTS.
| Project/Area Number |
05454373
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | KYOTO PREFECTURAL UNIVERSITY OF MEDICINE |
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Principal Investigator |
TAKAHASHI Toshio KYOTO PREFECTURAL UNIVERSITY OF MEDICINE,MEDICAL SCHOOL,INSTRUCTOR, 医学部, 教授 (50079828)
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| Co-Investigator(Kenkyū-buntansha) |
OTSUJI Eigo KYOTO PREFECTURAL UNIVERSITY OF MEDICINE,MEDICAL SCHOOL,ASSISTANT, 医学部, 助手 (20244600)
KITAMURA Kazuya KYOTO PREFECTURAL UNIVERSITY OF MEDICINE,MEDICAL SCHOOL,ASSISTANT, 医学部, 助手 (10224966)
YAMAGUCHI Toshiharu KYOTO PREFECTURAL UNIVERSITY OF MEDICINE,MEDICAL SCHOOL,INSTRUCTOR, 医学部, 講師 (90111327)
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| Project Period (FY) |
1993 – 1994
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| Keywords | MONOCLONAL ANTIBODY / IMAGING / INTRAOPERATIVE DIAGNOSIS / IMMUNO-GUIDED SURGERY / Immuno-guided Surgery |
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| Research Abstract |
MONOCLONAL ANTIBODY WAS LABELED WITH ^<131>I OR ^<111>In. THE SENSITIVITY OF ^<111>In WAS BETTER THAN THAT OF ^<131>I,THOUGH NON SPECIFIC ACCUMULATION OF LABELED ANTIBODY WAS HIGHER IN ^<111>In LABELED ANTIBODY.METASTATIC LESION OF COLON CANCER WAS DETECTED BY INTRAOPERATIVE SURVEY USING MINI-PROBE FOR GAMMA-RAY DETECTION.BUT THE SENSITIVITY WAS NOT SATISFACTORY IN CASE OF SMALL METASTASIS.HISTOLOGICAL AUTORADIOGRAPHY SHOWED SELECTIVE ACCUMULATION OF LABELED ANTIBODY TO CANCER TISSUE AND NON-SPECIFIC DISTRIBUTION TO NORMAL MUCOSA WAS MINIMUM.CLINICAL DATA SHOWED THAT 5mCi OF LABELED ANTIBODY WAS ENOUGH TO DETECT METASTATIC LE-SION.AND SCANNING AT 48 HOURS AFTER ADMINISTRATION OF LABELED ANTIBODY SHOWED BEST IMAGE OF CANCER LESION.RADIOIMMUNOGUIDED SURGERY WAS USUEFUL INCASE OF DECIDING THE LIMIT OF EXCISION TUMOR.FROM THESE RESULTS,IMMUNO-GUIDED SURGERY USING RADIOLABELED MONOCLONAL ANTIBODY SEEMED TO BE PROMISING METHOD FOR CANCER SURGERY.
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