1994 Fiscal Year Final Research Report Summary
Study on Cerebral Blood Flow, Cerebral Metabolism and Pathological Changes in Cerebral Venous Occlusion
| Project/Area Number |
05454401
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Nara Medical University |
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Principal Investigator |
SAKAKI Toshisuke Nara Medical University, Professor, 医学部, 教授 (20118029)
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| Project Period (FY) |
1993 – 1994
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| Keywords | Cerebral vein / Sinus thrombosis / Venous infarction |
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| Research Abstract |
Research consisted of three studies. The first study is measurement of local cerebral blood flow in cerebral venous occlusion with autoradiography after intravenous injection of C^<14> -iodoantipyrine. The second is the study of serial measurement of extracellular lactate concentration with microdyalysis, and measurement of glucose metabolism using autoradiography after intravenous injection of C^<14> -deoxyglucose. The third study is to investigate the blood-brain barrier disruption and pathological changes of the cerebral vein on surgical occlusion of the cortical vein and brain retraction. In the first and second studies, occlusion of the superior sagittal sinus and cortical veins was performed with intrasinus injection of cyanoacrylate. If the occlusion was localized in the sinus, cerebral blood flow and cerebral glucose metabolism were maintained in the physiological values. If the cortical veins were occluded with retrograde filling of cyanoacrylate, remarkable decreasing of cerebral blood flow, increasing of extracellular lactate and marked disturbance of glucose metabolism occurred in the more extent area than the territories from which blood was washed out by the involved cortical veins. And the third study showed that both loadings of cortical vein occlusion and brain retraction induce remarkable blood-brain barrier disruption secondary to extent venous intimal injuries and intravenous thrombus formation.
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