1994 Fiscal Year Final Research Report Summary
Pharmacokinetic study for target controlled infusion of ketamine and fentanyl
| Project/Area Number |
05454412
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | HIROSAKI UNIVERSITY |
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Principal Investigator |
MATSUKI Akitomo Hirosaki University School of Medicine, Professor, 医学部, 教授 (20003543)
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| Co-Investigator(Kenkyū-buntansha) |
KUDO Tsuyoshi Hirosaki University School of Medicine, Instructor, 医学部, 助手 (70003407)
HASHIMOTO Hiroshi Hirosaki University Hospital, Instructor, 医学部・附属病院, 助手 (00218421)
ISHIHARA Hironori Hirosaki University School of Medicine, Associate Professor, 医学部, 助教授 (50111224)
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| Project Period (FY) |
1993 – 1994
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| Keywords | Pharmacokinetics / Fentanyl / Ketamine / Target controlled infusion / Total intravenous anesthesia |
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| Research Abstract |
With the help of pharmacokinetic principles it is possible to develop infusion schemes that rapidly obtain an predefined blood concentration of the infused drug and thereafter maintain this concentration. An example of such a scheme is the two-stage (2mg/kg, 2mg/kg/h)infusion regimen for ketamine intended to maintain the blood concentration at 1.0mug/ml. However, the requirement for anesthetic drugs varies from patient to patient and also for an individual patient according to the nature and intensity of the surgical stimulus. The differential equations involved in calculating the infusion rates needed to achieve and maintain a given target blood concentration are too complicated to perform by hand in the operating theater. For a computer these calculations are easy to perform and infusion schemes can be calculated for any target blood concentration in real time. By connecting a computer to a remotely controllable infusion pump a system is obtained with which intravenous drugs can be delivered with greater ease than inhalation anesthetics with a vaporizer. These systems are called computer controlled infusion devices or Target Controlled Infusion Devices (TCI) . Hirosaki was the first centers involved in the evaluation of these new systems in Japan. Another study results which we performed was a scheme of fentanyl infusion dose including 5-15mug/kg to get 3-5ng/ml blood concentration.
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