1994 Fiscal Year Final Research Report Summary
Basic study on the factors regulating the postnatal development of the masticatory organ and center
| Project/Area Number |
05454489
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | HIROSHIMA UNIVERSITY |
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Principal Investigator |
MAEDA Norihiko Hiroshima School of University Dentistry Professor, 歯学部, 教授 (60049418)
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| Co-Investigator(Kenkyū-buntansha) |
NIIDA Shumpei Hiroshima School of University Dentistry Instructor, 歯学部, 助手 (10137630)
HOSOI Mitsuteru Hiroshima School of University Dentistry Associate Professor, 歯学部, 助教授 (00034190)
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| Project Period (FY) |
1993 – 1994
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| Keywords | Masticatory system / Masseter muscle / Postnatal development / Sexual dimorphism / Androgenic hormones / Peridontal ligaments / Trigeminal motor neuron / Trigeminal sensory neuron |
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| Research Abstract |
Postnatal changes in the masticatory system and regulation factors were investigated, and following results were obtained.
1.Sexual dimorphism of isozyme patterns of lactate dehydrogenase gradually appeared in the masseter muscle of developing mice. Testectomy inhibited the appearance, but not ovariectomy.
2.Androgenic hormones induced the sexual differences in the masseter muscle. Cyproterone acetate which is an androgen antagonist inhibited the induction.
3.Androgen receptors were certainly observed in masseter muscles of male and female mice. The receptors apppeared with maturation of male and female animals. No sexual difference was observed.
4.Short-term denervation of the masseter nerve did not inhibit the appearance of sexual dimorphism in the masseter muscle.
5.Sexual dimorphism in the trigeminal motor neurons innervating the mouse masseter muscle was observed. Estrogenic and androgenic hormones were involved in induction of the dimorphism.
6.Less-developed periodontal ligaments in op/op mice caused the precocious atrophy of the masseter muscle, and induced the reduction in the number of motor and sensory neurons involved in the jaw-opening reflex in the mice.
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[Publications] Maeda, N., Sugiyama, H., Suemune, S., Wakisaka, H., Niida, S., Ogata, K.and Miyata, K.: "Sexual Dimorphism in the trigeminal motorneurons innervating the mouse masseter muscle" Brain Res.627. 177-180 (1993)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Sekino, K., Suzuki, Y., Miyata, K., Osawa, K., Suemune, S., Hosoi, M., Niida, S., Wakisaka, H.and Maeda, N.: "Sexual dimorphism of isozyme patterns of lactate dehydrogenase and effects of testectomy and ovariectomy of the isozyme distribution in the masseter muscle and tongue of mice" Biomedical Res.14. 49-55 (1993)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Maeda, N., Suzuki, Y., Miyata, K., Wakisaka., Niida, S., Suemune, S.and Okada, N.: "Effects of androgenic hormones on the expression of isozymes of lactate dehydrogenase in the masseter muscle and tongue of mice" Biomedical Res.14. 233-241 (1993)
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「研究成果報告書概要(欧文)」より
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[Publications] Maeda, N., Ogata, K., Hosoi, M., Sato, S., Maruyama, S.and Okamato, H.: "Postnatal changes in the intensity of immuno-histochemical reaction to androgen receptor antibody in mouse masseter muscle" Biomedical Res.15. 89-93 (1994)
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「研究成果報告書概要(欧文)」より
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[Publications] Maeda, N., Kawata, T., Yoshiko, Y., Hosoi, M., Suemune, S., Okada, N.and Tanne, K.: "Postnatal changes in the masseter muscle of the toothless (op/op) mouse with less-developed periodontal ligaments" Biomedical Res.15. 255-261 (1994)
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「研究成果報告書概要(欧文)」より
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[Publications] Maeda, N., Suzuki, Y., Suemune, S., Okada, N., Yoshiko, Y.and Akagawa, Y.: "Effects of denervation on the expression of lactate dehydrogenase isozymes in the masseter muscle of developing mice" Biomedical Res.15. 287-290 (1994)
Description
「研究成果報告書概要(欧文)」より
