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1994 Fiscal Year Final Research Report Summary

Study on the pathological absorption of maxillary bone induced by mechanical stress

Research Project

Project/Area Number 05454537
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionHIROSAKI UNIVERSITY

Principal Investigator

KIMURA Hiroto  Hirosaki University School of Medicine, Oral Surgery, Professor, 医学部, 教授 (90142851)

Co-Investigator(Kenkyū-buntansha) KOBAYASI Wataru  Hirosaki University Hospital, Oral Surgery, Assistant professor, 医学部・附属病院, 講師 (50234860)
Project Period (FY) 1993 – 1994
Keywordsjaw cyst / bone absorption / mechanical stress / intracystic pressure / microcirculation / lipid peroxide / antioxidant enzyme / cytokine
Research Abstract

To solve the relationship between the physical force ( =mechanical stress)and the bone absorption in jaw cysts, we tried to measure directly intracystic pressure and colloid osmotic pressure of cyst fluids. The cyst wall microcirculation was also measured by laser doppler blood flow meter. Using cyst wall tissues as materials, we tried to detect lipid peroxide by chemiluminescence-HPLC method, prostanoid and inflammatory cytokines by ELISA.Furthermore, the localization of lipid peroxide and antioxidant enzyme in cyst wall were investigated by the histochemical method. Results were as follows.
1. The average of intracystic pressure was 27.4mmHg, which was a good correlation with the colloid osmotic pressure, and changed with the degeneration of cyst fluid accompanying with bacterial infection or inflammation. No correlation could be found between the pressure and the histological typing of jaw cysts. 2. The blood flow of cyst wall showed lower value than healthy-side gingival mucosa. 3. … More PGE_2, IL-1betaIL-6, TNF alpha were detected in cyst wall. Values of these factors were in propotion to the degree of inflammation in jaw cysts. 4.Cu, Zn-SOD was localized at the inner side of cyst wall epitelium and at the capillary endothelial epithelium in cyst wall connective tissue. This finding was in good accordance with both pathohistological finding of inflammation and the localization of lipid peroxide staining in jaw cyst wall.
These results in this study revealed that the increase of intracystic pressure was induced by the free radicals-mediated tissue injury and that the microcirculation in cyst wall was also damaged by the increasing of the colloid osmotic pressure of cyst fluid. These findings strongly suggested that the microvascular injury was responsible for the generation of bone absorbing factor. In clinical study, jaw cyst gradually decreased in size according to the declines of intracystic pressure by the irrigation therapy, which aspirate cyst fluid regularly to change physiological saline including antioxidant reagents. Less

  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] 木村博人,高地義孝: "骨吸収におけるプロスタグランジンとサイトカインの役割" 歯科ジャーナル. 39. 387-393 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 佐藤 寿,木村博人他: "CL-HPLC法による顎嚢胞壁組織の過酸化脂質の測定" 過酸化脂質研究. 18. 277-280 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小川 透,木村博人他: "顎嚢胞壁の脂質過酸化と微小循環動態の傷害について" 過酸化脂質研究. 18(印刷中). (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 秋田谷 徹,木村博人他: "顎嚢胞性疾患におけるCu,Zn-SODの局在に関する免疫組織化学的研究" 過酸化脂質研究. 18(印刷中). (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiroto KIMURA,Yositaka TAKACHI: "The role of prostaglandins and cytokines in bone absorption." The Journal of Dental Medicine. 39-4. 387-393 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hisasi SATOU,Hiroto KIMURA et al.: "Measurement of lipid peroxide in cyst wall tissues by CL-HPLC method." Lipid Peroxide Research. 18-2. 277-280 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tohru OGAWA,Hiroto KIMURA et al.: "Lipid peroxide and microcirculation injury of jaw cyst wall." Lipid Peroxide Research. 18-3, (in press, ). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tohru AKITAYA,Hiroto KIMURA et al.: "Immunohistochemical study on the localization of Cu, Zn-SOD in the tissue of jaw cysts." Lipid Peroxide Research. 18-3, (in press, ). (1995)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1996-04-15  

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