1995 Fiscal Year Final Research Report Summary
Immuno histochemical Studies on degenerated disc and retro discal tissue in the internal deraugement of the temporo mandibular joint.
| Project/Area Number |
05454540
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
IIZUKA Tadahiko Professor, School of Medicine, KYoto Univ., 医学研究科, 教授 (80026921)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Hiroaki Assistant Professor, School of Medicine, KYoto Univ., 医学研究科, 助手 (40260624)
MORIYA Yoshiyuki Assistant Professor, School of Medicine, KYoto Univ., 医学研究科, 助手 (70221637)
FUJITA Shigeyuki Lecturer, School of Medicine, KYoto Univ., 医学研究科, 講師 (50228996)
MURAKAMI Ken-ichiro Associate Professor, School of Medicine, KYoto Univ., 医学研究科, 助教授 (00174269)
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| Project Period (FY) |
1993 – 1995
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| Keywords | Internal derangement / Keratin sulfate / Hyaluronic acid / Chondoritin 6-sulfate / Tenascin / CD44 / MR imaging |
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| Research Abstract |
We studied TMD patients with internal derangement by MR imaging and arthroscopic surgery. It is resulted that closed lock cases had close relationship between adhesion and maximum opening, and that between adhesion and pain.
The human TMJ specimens obtained at autopsy were examined immunohistochemically. In cases with anterior disc displacement, keratin sulfate and chondroitin 6-sulfate were highly localized in the anterial area of TMJ discs. These findings suggested that there is relationship between the distribution of extracellular matrix and pathological changes of the human TMJ.
We examined surgical specimens of human TMJ immunohistochemically. CD44 distributed intensively in human synovi al membrane. We found there were many distribution of hyaluronic recepter in the synovial membrane. TGF-beta and tenascin were expressed intensively in the affected human synovial menbarane These findings suggested that tenascin might be an useful marker for grade of synovitis.
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