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1994 Fiscal Year Final Research Report Summary

Studies on microcirculation influences tissue activity of the Oral Mucousa in Diabetics

Research Project

Project/Area Number 05454547
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionTOKYO DENTAL COLLEGE

Principal Investigator

KATAGIRI Sigeo  Tokyo Dental College, Dentistry, Professor, 歯学部, 教授 (70085752)

Co-Investigator(Kenkyū-buntansha) BABA Ryoko  Tokyo Dental College, Assistant., 歯学部, 助手 (20156540)
MORIMOTO Mitsuaki  Tokyo Dental College, Assistant., 歯学部, 助手 (90174458)
MIZUNO Yoshio  Tokyo Dental College, Professor., 歯学部, 教授 (40051750)
Project Period (FY) 1993 – 1994
KeywordsDiabetics / Microangiopathy / Oral mucosa / Microcirculation / Vital Video-Microscopic System / Capi-Flow / PtO_2 / BrudU L.I.
Research Abstract

In present study, we have attempted to clarify in the relationship between microcirculatory disturbance and tissue oxygon tension, cell kinetics of Oral mucosa in Diabetics. The results were as follows.
1 Significant findings of microcirculation were evidence of slow circulation, meandering in microvessels, irregularly vessel wall, abnormal architecturs and dicrease of visibility.
2 PtO2 levels in diabetics, 26.5(]SY.+-。[)9.5mmHg decreased significantly compared with that in control, 41.3(]SY.+-。[)3.7mmHg (p<0.01) .PtO2 levels correlated with HbA<@D21c@>D2 (r=-0.44p<0.01) and BrdU L.I.(r=0.53 p<0.01). Further, PtO2 levels correlated with abnormalities in microcirculation (r=-0.48 p<0.01) and progress of diabetic retinopathy (r=0.58 p<0.01).
3 PtO2 levels in insulin-treated diabetics were different in the individual patients. These data indicated PtO2 levels reflected the diabetic control and the influence of diabetic microangiopathy in oral mucosa.
4 Vital Video-microscopic system for observing the microcirculation, measurement of PtO2 levels, which is simple, noninvasive and valuable technique may be a useful predictor on the localization and progression at early stage of diabetic microangiopathy, further, these methods seemed to be very efficiant for futuer development of any complications with past-operative inflammation or relardation of wound healing in oral mucosa.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] 森本光明: "糖尿病患者における口腔粘膜毛細血管生体ビデオ観察所見" 糖尿病. 36. 189- (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 鈴木雄一: "糖尿病患者における口腔粘膜上皮の細胞動体に関する研究-llbA_<1c>と組織酸素分圧(PtO_2)との関連-" 糖尿病. 37. 438- (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 森崎重規: "糖尿病患者口腔粘膜の毛細血管に関する研究-糖尿病性慢性合併症と血中トロンボモジュリン値-" 歯科学報. 11. 986- (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 森本光明: "糖尿病患者口腔粘膜における微小循環異常に関する研究" 第254回東京歯科大学学会(3月,千葉). (発表予定). (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 鈴木雄一: "糖尿病患者における口腔粘膜上皮の細胞動体に関する研究-網膜症との関連について-" 第38回日本糖尿病学会年次学術集会(5月,大宮). (発表予定). (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 片桐重雄: "Evalution of PtO_2 Measurement on the Oral Mucose in Diabetics." The IADR 73rd General Session (June, Singapore). (発表予定). (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] MORIMOTO,M., etc.: "Vital Video-Microscopic System for obsarving the microcirculation of oral mucosa in Diabetics." J.Jap.Diab.Soc.36. 189 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] SUZUKI,Y., etc.: "A Study on cell kinetics of oral mucosa in Diabetics. - Correlation between HbA_<1c> and PtO_2" J.Jap.Diab.Soc.37. 438 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] MORIMOTO,M., etc.: "Studies on the oral mucosa vessels in Diabetics. -Correlation between the chronic complication of Diabetes and blood thrombomodulin-" The SHIKWA GAKUHO. 11. 986 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] MORIMOTO,M., etc.: "A Study on Abnormalities in Microcirculation of oral mucosa in Diabetics" The 254rd Tokyo Dental College Society (Chiba), March. (in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] SUZUKI,Y., etc.: "A Study on cell kinetics of oral mucosa in Diabetics. - Relationship with diabetic retinopaty -" The 38rd Japan Diabetes Society General session (Omiya), May. (in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] KATAGIRI,S., etc.: "Evalution of PtO_2 measurment on the oral mucosa in Diabetics." The IADR 73rd General session (Singapore), June. (in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-03-09  

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