1994 Fiscal Year Final Research Report Summary
Studies on microcirculation influences tissue activity of the Oral Mucousa in Diabetics
| Project/Area Number |
05454547
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | TOKYO DENTAL COLLEGE |
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Principal Investigator |
KATAGIRI Sigeo Tokyo Dental College, Dentistry, Professor, 歯学部, 教授 (70085752)
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| Co-Investigator(Kenkyū-buntansha) |
BABA Ryoko Tokyo Dental College, Assistant., 歯学部, 助手 (20156540)
MORIMOTO Mitsuaki Tokyo Dental College, Assistant., 歯学部, 助手 (90174458)
MIZUNO Yoshio Tokyo Dental College, Professor., 歯学部, 教授 (40051750)
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| Project Period (FY) |
1993 – 1994
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| Keywords | Diabetics / Microangiopathy / Oral mucosa / Microcirculation / Vital Video-Microscopic System / Capi-Flow / PtO_2 / BrudU L.I. |
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| Research Abstract |
In present study, we have attempted to clarify in the relationship between microcirculatory disturbance and tissue oxygon tension, cell kinetics of Oral mucosa in Diabetics. The results were as follows.
1 Significant findings of microcirculation were evidence of slow circulation, meandering in microvessels, irregularly vessel wall, abnormal architecturs and dicrease of visibility.
2 PtO2 levels in diabetics, 26.5(]SY.+-。[)9.5mmHg decreased significantly compared with that in control, 41.3(]SY.+-。[)3.7mmHg (p<0.01) .PtO2 levels correlated with HbA<@D21c@>D2 (r=-0.44p<0.01) and BrdU L.I.(r=0.53 p<0.01). Further, PtO2 levels correlated with abnormalities in microcirculation (r=-0.48 p<0.01) and progress of diabetic retinopathy (r=0.58 p<0.01).
3 PtO2 levels in insulin-treated diabetics were different in the individual patients. These data indicated PtO2 levels reflected the diabetic control and the influence of diabetic microangiopathy in oral mucosa.
4 Vital Video-microscopic system for observing the microcirculation, measurement of PtO2 levels, which is simple, noninvasive and valuable technique may be a useful predictor on the localization and progression at early stage of diabetic microangiopathy, further, these methods seemed to be very efficiant for futuer development of any complications with past-operative inflammation or relardation of wound healing in oral mucosa.
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