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1995 Fiscal Year Final Research Report Summary

Neurophysiological and anatomical investigation-The paraflocculus-cerebellar nuclear control mechanisms of the primate smooth pursuit eye movement system

Research Project

Project/Area Number 05454676
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Neuroscience in general
Research InstitutionJichi Medical School

Principal Investigator

NAGAO Soichi  Faculty of Madicine, Jichi Medical School, Associate Professor., 医学部, 助教授 (40164397)

Project Period (FY) 1993 – 1995
Keywordscerebellum / vestibulo-ocular reflex / smooth pursuit eye movement / primate / control / flocculus / paraflocculus
Research Abstract

The neural mechanisms for the short-term adaptation of the vestibulo-ocular reflex (VOR) has been investigated as an experimental model of the cerebellar motor control. My results of lesion, single unit recording and circuitry analysis studies in the rabbit and monkey experiments consistently support the hypothesis that the flocculus adaptively controls the gain of the VOR through the long-term depression (LTD) of transmission efficacy of the synapses on the Purkinje cells within the flocculus. To this flocculus hypothesis, a different role of the flocculus is proposed in the monkey VOR that the adaptation of the VOR is induced by the cooperation of the flocculus and its target neurons in the brain stem (Lisberger and Sejnowski 1993). To this proposal, however, my neuroanatomical study using retrograde and/or anterograde axonal flow methods and study of unit recording experiments reveal that the caudal half of the monkey flocculus has the characteristics for the control of the VOR,but the rostral half of it has the characteristics for the control of smooth pursuit. So I suggest that the rostral half of the monkey flocculus belongs to the ventral paraflocculus. The experimental observations reported by the Lisberger's group seem to include thoses obtained in the ventral paraflocculus. Therefore, I suggest that the flocculus and ventral paraflocculus respectively controls the vestibulo-ocular and smooth pursuit eye movements in the primate. My behavioral study using the adaptation of the primate VOR and those for the adaptation smooth pursuit eye movements also support the view that these two slow eye movements are independently controlled by the different groups of neurons in the cerebellum.

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Nagao,S.,et.al.: "Neural circuitry underlying VOR plasticity." J.Vestibular Research. 印刷中 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 永雄総一: "ウサギ前庭動眼反射" 生体の科学. 45. 412-413 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 永雄総一: "ウサギ瞬膜反射" 生体の科学. 45. 414-415 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 永雄総一: "小脳の運動学習機構" 生体の科学. 47. 43-49 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nagao,S.,Kitamura T., Nakamura,N.,Hiramatsu,T.& Yamada,J.: "Differences of flocculus and ventral paraflocculus in the oculomotor contor of primates. I.mossy and climbing fiberl inputs." J.Comp.Neurol.発表予定 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nagao,S.,Kitamura T., Nakamura,N.,Hiramatsu,T.& Yamada,J.: "Differences of flocculus and ventral paraflocculus in the oculomotor contorl of primates. II.efferent teminals." J.Comp.Neurol.発表予定 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nagao,S.: "A neural design for the cerebellar control systen of the smooth pursuit eye movement. Brain Proccesses and Memory." Elsevier, 印刷中 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nagao, S.: "Primate eye fields in the deep cerebellar nuclei determined by local stimulation technique." Neurosci.Res.Suppl.19 : S175. 1613 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagao, S.: "Pharmacological effects of R-THBP on the cerebellar functions estimated with changes of dynamics of rabbit vestibulo-ocular reflex eye movements." Pteridines. 5. 43 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagao, S., Kitamura, T., Nakamura, N., Hiramatsu, T.& Yamada, J.: "Differences of flocculus and ventral paraflocculus in the oculomotor control of primates. I.mossay and climbing fiber inputs." J.Comp.Neurol.(submitted). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagao, S., Kitamura, T., Nakamura, N., Hiramatsu, T.& Yamada, J.: "Differences of flocculus and ventral paraflocculus in the oculomotor control of primates. II.efferent terminals." J.Comp.Neurol.(submitted). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagao, S., Kitamura, T.& Yamada, J.: "Neural circuitry underlying VOR plasticity" J.Vestibular Research. (in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagao, S.: "A neural design for the cerebellar control system of the smooth pursuit eye movement." Brain Processes and Memory, Elsevier. (in press). (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagao, S.: "Rabbit vestibulo-ocular reflex." Seitai Kagaku. 45 (in Japanese). 412-413 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagao, S.: "Rabbit nictitating membrane response." Seitai Kagaku. 45 (in Japanese). 414-415 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagao, S.: "Cerebellar motor learning mechanism." Seitai Kagaku. 47 (in Japanese). 43-49 (1996)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1997-03-04  

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