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1994 Fiscal Year Final Research Report Summary

Development of intravascular targeting hyperthermia using dextran magnetite complex

Research Project

Project/Area Number 05557046
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

HIRAOKA Masahiro  Kyoto Univ.Fac.of Associate Medicine Prof., 医学部, 助教授 (70173218)

Co-Investigator(Kenkyū-buntansha) NAGAE Hideo  Meito Indust.Co.Nagoya Chief Research Institute, 名古屋研究所, 主任研究員
NAGATA Yasushi  Kyoto Univ.Fac.of Assist.Medicine Prof., 医学部, 助手 (10228033)
NISHIMURA Yasumasa  Kyoto Univ.Fac.of Lecturer Medicine, 医学部, 講師 (00218207)
Project Period (FY) 1993 – 1994
KeywordsHyperthermia / Intravascular / Embolization / Magnetic Fluid / Dextran Magnetite Complex
Research Abstract

This is a fundamental study to develop an "intravascular targeting hyperthermia" , in which a deep seated tumor is heated using an intravascularly administered magnetic material together with an externally applied AC magnetic field. As a heat generating material, we employed dextran magnetite complex (DM) , which is a kind of 'magnetic fluid'. The heat production of DM in an AC magnetic field is much higher than previously reported multidomain ferrite particles due to a different mechanism of heat generation. We designed two DM-containing embolic materials, a DM/Lipiodol(]SY.encircledR.[) emulsion and a DM/degradable starch microsphere (DM/DSM) suspension. In vitro experiments showed that the heat generating capacity of DM was not reduced in these preparations. When these materials were injected into the renal arteries of Japanese white rabbits, they achieved selective heating (over 10゚C/10min.) of the embolized kidney following exposure to a 100kHz AC magnetic field of approximately 1 … More 5000 A/m. The average iron concentration in the embolized kidney was 4.9 (]SY.+-.[) 2.4mg Fe/g tissue. A similar experiment with a VX2 tumor transplanted in the liver of a rabbit demonstrated sufficient heating of the tumor. With current composition of DM containing embolic material, DM escapes into systemic circulation and is trapped by reticulo endothelial system (RES) within 6 hours of intraarterial administration. Moreover, an experiment using C3H mouse model revealed that the heat generating capacity of DM is decreased as it is metabolize13EA01 : This is a fundamental study to develop an"intravascular targeting hyperthermia" , in which a deep seated tumor is heated using an intravascularly administered magnetic material together with an externally applied AC magnetic field. As a heat generating material, we employed dextran magnetite complex (DM) , which is a kind of 'magnetic fluid'. The heat production of DM in an AC magnetic field is much higher than previously reported multidomain ferrite particles due to a different mechanism of heat generation. We designed two DM-containing embolic materials, a DM/Lipiodol(]SY.encircledR.[) emulsion and a DM/degradable starch microsphere (DM/DSM) suspension. In vitro experiments showed that the heat generating capacity of DM was not reduced in these preparations. When these materials were injected into the renal arteries of Japanese white rabbits, they achieved selective heating (over 10゚C/10min.) of the embolized kidney following exposure to a 100kHz AC magnetic field of approximately 15000 A/m. The average iron concentration in the embolized kidney was 4.9 (]SY.+-.[) 2.4mg Fe/g tissue. A similar experiment with a VX2 tumor transplanted in the liver of a rabbit demonstrated sufficient heating of the tumor. With current composition of DM containing embolic material, DM escapes into systemic circulation and is trapped by reticulo endothelial system (RES) within 6 hours of intraarterial administration. Moreover, an experime Less

  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Ikenaga, M. , et al: "Hyperthermic treatment of canine tibia through RF inductive heating of an intramedullay nail." Int. J. Hyperthermia. 10. 507-516 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsumoto, M. , et al: "Ferromaguetic hyperthermia in rabbit eyes using a new glass-ceramic thermossed." Graefe's Arch. Clin. Exp. Ophthalmol.232. 176-181 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiraoka, M. , et al: "Clinical evaluation of a 430 MHz microwave hyperthermia system with a lens Applicator for cancer therapy." Medical & Biological Engineering & Comp.In press.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nagata, Y. , et al: "Clinical experiences in the thermoraiontherapy for advanced gastric cancer." Int. J. Hyperthermia. In press.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiraoka, M, et al: "In Pinciples and Practice of Thermoradiotherapy." Seegenschmiedt, M. H. Fessenden, P. Vernon C. C. (In press),

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ikenaga, M., et al: "Hyperthermic treatment of canine tibia through RF inductive heating of an intramedullay nail." Int.J.Hyperthermia. 10. 507-516 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matumoto, M., et al: "Ferromagnetic hyperthermia in rabbit eyes using a new glass-ceramic thermossed." Graefe's Arch.Clin.Exp.Ophthaolmol. 232. 176-181 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiraoka, M., et al: "Clincal evaluation of a 430 MHz microwave hyperthermia system with a lens applicator for cancer therapy." Medical & Biological. (In press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagata, Y., et al: "Clinical experiences in the thermoradiotherapy for advaced gactric cancer." Int.J.Hyperthermia.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagata, Y., et al: "Clinical experiences in the thermoradiotherapy for advaced gactric cancer." Int.J.Hyperthermia. (In press).

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1996-04-15  

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