1995 Fiscal Year Final Research Report Summary
Development of drug for peritoneal carcinomatosis using angiogenic inhibitor.
| Project/Area Number |
05557062
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| Research Category |
Grant-in-Aid for Developmental Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
HAGIWARA Akeo Kyoto Prefectural University of Medicine, Surgery 1, Lecturer, 医学部, 講師 (90198648)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMOTSUMA Masataka Kyoto Prefectural University of Medicine, Surgery 1, Assistant, 医学部, 助手 (30244601)
TAKAHASHI Toshio Kyoto Prefectural University of Medicine, Surgery 1, Professor, 医学部, 教授 (50079828)
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| Project Period (FY) |
1993 – 1995
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| Keywords | peritoneal carcinomatosis / angiogenic inhibitor / cancer metastases / chemotherapy |
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| Research Abstract |
Angiogenic inhibitors are expected as a new anti-cancer drug. It has not been confirmed that angiogenic inhibotors have therapeutic effects on peritoneal carcinomatosis. We examined the effects of one of the angiogenic inhibitors, TNP-470, on peritoneal carcinomatosis in mice.
TNP-470 in aqueous solution form showed a therapeutic effect when given in an early stage of the disease, while did not in advanced stages. The main side effect of the aqueous TNP-470 was accumulation of ascites induced through osmotic effects by emulsifying agent, sometimes generating a lethal toxicity.
TNP-MS,comprizing TNP-470 in the form of microspheres, was shown to be a dosage from preserving the drug activity, and TNP-MS releases the drug in an active from for a prolonged period of time, in the paritoneal cavity in animals. By these characteristics, TNP-MS achieved a therapeutic effect when administered in relatively advanced stages of peritoneal carcinomatosis in mice.
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