1995 Fiscal Year Final Research Report Summary

Regulatory compound of nuclear receptor functions.

Research Project

Project/Area Number	05557109
Research Category	Grant-in-Aid for Developmental Scientific Research (B)
Allocation Type	Single-year Grants
Research Field	医薬分子機能学
Research Institution	University of Tokyo, Faculty of pharm.Sciences
Principal Investigator	SHUDO Koichi The University.of Tokyo Fac.Pharm.Sci.Propessor, 薬学部, 教授 (50012612)
Co-Investigator(Kenkyū-buntansha)	KAGECHIKA Hiroyuki The University.of Tolyo Fac.Pharm.Sci.Assostant Prof., 薬学部, 助手 (20177348)
Project Period (FY)	1993 – 1995
Keywords	retinoid / tyroids / retinoic acid / differentiation / HL60 / leukemia / myeloma / antagonist synergist
Research Abstract	New retinoids and steroids, tyroids are designed and synthesized. Methods for a divergent reaction were illustrated. Tyroids with trifluoromethyl group were proved to be active. Retinoids syhnthesized proviously were proved to be a candidate for the treatment of acute promyelocytic leukemia and for the treatment of arthrites rheumatoid. 4 [5H-2,3- (2,5-dimethy12,5-jexano-5-methyldibenzodiazepin-1-ylbenzpic acid enhanced the differentiation inducing activity of retinoic acid and of a synthetic retinoid Am80 toward human promyelocytic leukemia cells, although the compound itself did not induce differentiation. The synergedstic effect of the compound was also seen in supression of HL60 cells.

(8 results)