1995 Fiscal Year Final Research Report Summary
Regulatory compound of nuclear receptor functions.
| Project/Area Number |
05557109
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| Research Category |
Grant-in-Aid for Developmental Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
医薬分子機能学
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| Research Institution | University of Tokyo, Faculty of pharm.Sciences |
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Principal Investigator |
SHUDO Koichi The University.of Tokyo Fac.Pharm.Sci.Propessor, 薬学部, 教授 (50012612)
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| Co-Investigator(Kenkyū-buntansha) |
KAGECHIKA Hiroyuki The University.of Tolyo Fac.Pharm.Sci.Assostant Prof., 薬学部, 助手 (20177348)
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| Project Period (FY) |
1993 – 1995
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| Keywords | retinoid / tyroids / retinoic acid / differentiation / HL60 / leukemia / myeloma / antagonist synergist |
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| Research Abstract |
New retinoids and steroids, tyroids are designed and synthesized. Methods for a divergent reaction were illustrated. Tyroids with trifluoromethyl group were proved to be active. Retinoids syhnthesized proviously were proved to be a candidate for the treatment of acute promyelocytic leukemia and for the treatment of arthrites rheumatoid. 4 [5H-2,3- (2,5-dimethy12,5-jexano-5-methyldibenzodiazepin-1-ylbenzpic acid enhanced the differentiation inducing activity of retinoic acid and of a synthetic retinoid Am80 toward human promyelocytic leukemia cells, although the compound itself did not induce differentiation. The synergedstic effect of the compound was also seen in supression of HL60 cells.
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