1995 Fiscal Year Final Research Report Summary
Development of gnobotiotic mice for screening of efficiency of Probiotics
| Project/Area Number |
05558103
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| Research Category |
Grant-in-Aid for Developmental Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ITOH Kikuji The Univ.of Tokyo, Fac.of Agriculture, Assoc.Prof., 農学部, 助教授 (50100045)
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| Co-Investigator(Kenkyū-buntansha) |
TERADA Atsushi Nippon Vet.& Anim.Sci.Univ., Food Hyglane, Prof., 畜産学部, 教授 (10060518)
UEMURA Takeshi Univ.of Osaka Prefecture, Fac.of Agricul., Prof., 農学部, 教授 (40081591)
SAWAZAKI Touru The Univ.of Tokyo, Fac.of Agriculture, Prof., 農学部, 教授 (00012047)
HIRAYAMA Kazuhiro The Univ.of Tokyo, Fac.of Agriculture, Assist.Prof., 農学部, 助手 (60208858)
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| Project Period (FY) |
1993 – 1995
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| Keywords | Gnotobiote / Probiotics / Intestinal flora / Pigs / VFA / Putrefactive products |
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| Research Abstract |
We attempted to produce pig-flora-associated mice (PFM) for screening of efficiency of probiotics. The composition of fecal microbiota and concentrations of fecal short chain fatty acids and putrefactive products were studied in pigs and PFM.Major components of fecal bacterial groups of pigs were able to colonize in the intestine of PFM,but the species of Bacteroidaceae and Streptococaceae were significantly different between pigs and PFM.Fecal putrefactive products in PFM were undetectable although concentrations of them in pigs were high level. Concentrations of the major components of SCFAs of PFM were similar to those of the inocula.
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