1994 Fiscal Year Final Research Report Summary

Development of Formation of Pyrimidine Ring by a Novel Combination of Units (C-N-C+N-C-C)

Research Project

Project/Area Number	05640605
Research Category	Grant-in-Aid for General Scientific Research (C)
Allocation Type	Single-year Grants
Research Field	Organic chemistry
Research Institution	Osaka Kyoiku University
Principal Investigator	ARIGA Masahiro Osaka Kyoiku University, Dept.of Education, Professor, 教育学部, 教授 (90030395)
Co-Investigator(Kenkyū-buntansha)	NISHIWAKI Nagatoshi Osaka Kyoiku University, Dept.of Education, Assistant, 教育学部, 助手 (30237763)
Project Period (FY)	1993 – 1994
Keywords	Nitropyrimidinone / Ring-transformation / Pyrimidine / Diformylamine
Research Abstract	Ring transformation of 3-Methyl-5-nitro-4 (3H) -one (1) with ammonia and either carbonyl compounds, possessing methylene, or their morpholine enamine at sealed tube in methanol or acetonitrile at 100ﾟC afforded pyrimidines. In the present investigation we provide a novel method for synthesis of pyrimidines including the condensation of C-N-C and a C-C-N units, namely, nitropyrimidinone 1 play a role of a precursor of former and the carbonyl compound and ammonia act as the latter. This type of general synthesis of pyrimidine has not been reported to our knowledge. It was also found in course of the investigation that aminolysis of 1 gave beta-nitroenamines which were useful as a building block in the synthesis of heterocyclic compounds.

(2 results)