1994 Fiscal Year Final Research Report Summary
Development of Formation of Pyrimidine Ring by a Novel Combination of Units (C-N-C+N-C-C)
| Project/Area Number |
05640605
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Organic chemistry
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| Research Institution | Osaka Kyoiku University |
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Principal Investigator |
ARIGA Masahiro Osaka Kyoiku University, Dept.of Education, Professor, 教育学部, 教授 (90030395)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIWAKI Nagatoshi Osaka Kyoiku University, Dept.of Education, Assistant, 教育学部, 助手 (30237763)
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| Project Period (FY) |
1993 – 1994
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| Keywords | Nitropyrimidinone / Ring-transformation / Pyrimidine / Diformylamine |
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| Research Abstract |
Ring transformation of 3-Methyl-5-nitro-4 (3H) -one (1) with ammonia and either carbonyl compounds, possessing methylene, or their morpholine enamine at sealed tube in methanol or acetonitrile at 100ﾟC afforded pyrimidines. In the present investigation we provide a novel method for synthesis of pyrimidines including the condensation of C-N-C and a C-C-N units, namely, nitropyrimidinone 1 play a role of a precursor of former and the carbonyl compound and ammonia act as the latter. This type of general synthesis of pyrimidine has not been reported to our knowledge. It was also found in course of the investigation that aminolysis of 1 gave beta-nitroenamines which were useful as a building block in the synthesis of heterocyclic compounds.
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