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1994 Fiscal Year Final Research Report Summary

Regulation of apolipoprotein A-I gene expression by ascorbic acid in scurvy-prone ODS-od/od rats.

Research Project

Project/Area Number 05660136
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 食品科学・栄養科学
Research InstitutionNagoya University

Principal Investigator

HORIO Fumihiko  Nagoya University, School of Agricultural Sciences, Department of Applied Biological Sciences, Associate Professor, 農学部, 助教授 (20165591)

Project Period (FY) 1993 – 1994
KeywordsAscorbic acid / Apolipoprotein A-I / Atherosclerosis / Vitamin C
Research Abstract

Apolipoprotein A-I (Apo A-I) is a major apolipoprotein of serum high density lipoprotein (HDL) , which transports cholesterol from peripheral tissues to liver. We observed that apo A-I in serum HDL was decreased in ascorbic acid (AsA) deficiency in scurvy-prone ODS-od/od rats. In this study, we examined the mechanism how AsA deficiency causes a low level Apo A-I in serum.
The Apo A-I mRNA level in the liver but not in the small intestine was decreased (50%) in AsA-deficient group compared to in the control group. As AsA deficiency did not affect the transcription rate of Apo A-I gene, AsA might be required to stabilize Apo A-I mRNA.Moreover, a lower level of albumin mRNA,a higher level of haptoglobin mRNA and a higher level of 1-acid glycoprotein mRNA in the liver was observed in ascorbic acid-deficienct rats compared to in the control rats. These changes in hepatic levels of mRNA including Apo A-I mRNA are also observed in acute phase or inflammation. At present, we are measuring the serum levels of interleukin-6, which is a major cytokine secreted in acute phase and inflammation, in ascorbic acid deficiency.

  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] Ikeda,S.: "Ascorbate deficiency decreases hepatic apolopoprotein A-I mRNA in a scurvy-prone rat(genotype ODS-od/od)." Biochem.J,.submitted.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Uchida,K.: "Acute nephrotoxicity of a carcinogenic iron chelate selective inhibition of a proteolytic conversion of 2u-globulin to the kidney fatty acid-binding protein." FEBS Letters. 357. 165-167 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ikeda, S.: "Ascorbate deficiency decreases hepatic apolipoprotein A-I mRNA in a scurvy-prone rat (genotype ODS-od/od)." Biochem.J.(submitted.).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uchida, K.: "Acute nephrotoxicity of a carcinogenic iron chelate selective inhibition of a proteolytic conversion of 2u-globulin to the kidney fatty acid-binding protein." FEBS Letters. 357. 165-167 (1995)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1996-04-15  

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