1994 Fiscal Year Final Research Report Summary
THE EFFECTS OF TRICHOTHECENE(T-2 TOXIN)IN THE INTESTINAL IMMUNITY AND THE SENSITIVITY TO LISTERIOSIS.
| Project/Area Number |
05660150
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
食品科学・栄養科学
|
|---|
| Research Institution | NATIONAL INSTITUTE OF HEALTH OF JAPAN |
|---|
Principal Investigator |
SUGITA-KONISHI Yoshiko NATIONAL INSTITUTE OF HEALTH,DEP.OF BIOMEDICAL FOOD RESEARCH RESEARCHER, 食品衛生微生物部, 研究員 (10195761)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
INOUE Satoshi NATIONAL INSTITUTE OF HEALTH,DEP.OF VETERINARY SCIENCE RESEACHER, 獣医科学部, 研究員 (90213157)
|
|---|
| Project Period (FY) |
1993 – 1994
|
| Keywords | TRICHOTHECENE / LISTERIOSIS / IMMUNOCOMPETENT CELLS / EXPOSURE / TNF-alpha / INF-gamma |
|---|
| Research Abstract |
In the first year, the effects of trichothecene(T-2 toxin)on the immunocompetent cells were examined. The short term-exposure with middle or high dose of T-2 toxin caused the decrease of weights and the number of T cells, B cells in thymus, spleen and blood. On the hand, the long term-exposure with low does induced the change of the population of the immunocompetent cells in the lympocytes in intestine. This result suggests that even the exposure with low does of T-2 toxin has the risk of the gastrointestinal infection.
In the last year, the effects of T-2 toxin on the sensitivity to listeriosis were examined. The mice exposured with middle dose of T-2 toxin showed the resistance to listeriosis though those immunocompetent cells were decreased. The production of TNF-alpha and INF-gamma in those mice rised than in no treatment mice. This result indicated the short term-exposure with trichothecene enhances the production of cytokines and then induces the acquisition the resistance to listeriosis.
|
