1994 Fiscal Year Final Research Report Summary
Engeineering of delta-endotoxin from Bacillus thuringiensis to make a new specificity.
| Project/Area Number |
05660385
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
SATO Ryoichi Tokyo University of Agriculture and Technology, Faculty of agriculture, Assistant Professor, 農学部, 助手 (30235428)
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| Project Period (FY) |
1993 – 1994
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| Keywords | Bacillus thuringiensis / delta-endotoxin / immunotoxin |
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| Research Abstract |
To make proteinaceous insecticides which has specificity against harmful insect pests, monoclonal antibodies as specific ligands agaist the proteins on the insect midgut and recombinant delta-endotoxin production system were prepared. After cloning of genes of the monoclonal antibodies we are going to make fused gene of monoclonal antibodies and the toxin and finally produce chimera delta-endotoxin with monoclonal antibody which is toxic to the host who has the antigenic proteins of the antibody.
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