1995 Fiscal Year Final Research Report Summary
Abnormality of free radical scavenging mechanism in skin fibroblasts with dementia of the Alzheimer type
| Project/Area Number |
05670558
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Tottori University |
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Principal Investigator |
URAKAMI Katsuya Tottori University, Department of Neurology, Assistant Lecturer, 医学部, 講師 (30213507)
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| Co-Investigator(Kenkyū-buntansha) |
ADACHI Yoshiki Tottori University, Department of Neurology, Assistant Lecturer, 医学部・附属病院, 助手 (80243385)
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| Project Period (FY) |
1993 – 1995
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| Keywords | Dementia of the Alzheimer type / Superoxide dismutase / Skin fibroblast / SOD |
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| Research Abstract |
We examined superoxide dismutase (SOD) mRNA in skin fibroblasts with dementia of the Alzheimer type (DAT). THE DAT patients were divided into three subgroups as follows : Group A : patients that developed rapidly ; Group B : patients that developed gradually ; Group C : patients that developed very slowly. We determined SOD mRNA levels by Northern blot analysis. SOD mRNA level in skin fibroblast decreased in DAT, especially Group A.The change of SOD mRNA was closely correlate with clinical course of DAT.The determination of SOD mRNA in skin fibroblast may be useful for the diagnosis of three subgroups of DAT.
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