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1994 Fiscal Year Final Research Report Summary

Alteration of isoform of alpha-1-acide glycoprotein at heart failure

Research Project

Project/Area Number 05670585
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

NOMURA Akikazu  HOKKAIDO UNIVERSITY,SCHOOL PF MEDICINE,DEPARTMENT OF CARDIOVASCULAAR MEDICINE,LECTURE, 医学部, 講師 (70180776)

Co-Investigator(Kenkyū-buntansha) IKEDA Ken  HOKKAIDO UNIVERSITY,HOKKAIDO UNIVERSITY HOSPITAL,DEPARTMENT OF PHARMACY,ASSISTAN, 医学部・附属病院, 助教授 (40203062)
Project Period (FY) 1993 – 1994
KeywordsAlpha-1-acide glycoprotein / Heart failure / HPLC / Number of binding site / Affinity constant / Suger
Research Abstract

We developed the isolation method of alpha-1-acid glycoprotein (AAG).AAG concentration in serum became hightest at 4th day after acute myocardial infarction and became to the original level in 2 weeks.Binding of disopyramide, which bind to AAG,was lowest at the 4th day and returnd to the original level in 2 weeks.Then we compared the protein binding characteristics of disopyramide for the isolated AAG of the 4th day and of 4th week.There was no change in dissociation constant between them.However, the number of binding sites was lower in 4th day AAG compared to 4th week one.We also measured the concentration of sugers of AAG.There was no change in fucose concentration between them.However, the concentrations of N-acetylglucosamin, galactose, mannose and N-acetylneuramic acid were higher in 4th day AAG compared to 4th week one.We concluded the constitutional change of AAG influenced the protein binding of the drug.

  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] Akikazu Nomura et al: "Digoxin dose adjusted according to estimated creatinine clearance in elderly patients with cardiac disease" Cardiol Elderly. 2. 139-143 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Akikazu Nomura et al: "Altered alpha-1-acid glycoprotein concentration and free fraction of disopyramide in patients with heart disease" Jpn J Clin Pharmacol Ther. 25. 413-418 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Satoshi Kishino et al: "Alpha-1-acid glycoprotein concentration and the protein binding of disopyramide in healthy subjects" J Clin Pharmacol. 35. (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Akikazu Nomura, Akira, Kitabatake, Satoshi Kishino, Ken Iseki, and Katsumi Miyazaki: "Digoxin dose adjusted according to estimated creatinine clearance in elderly patients with cardiac disease" Cardil Elderly. 2(2). 139-143 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Akikazu Nomura, Akira, Kitabatake, Satoshi Kishino, Zhai S.DI,Ken Iseki, and Katsumi Miyazaki: "Altered alpha-1-acid glycoprotein concentration and free fraction of disopyramine in patients with heart disease" Jpn J Clin Pharmacol Ther. 25(2). 413-418 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Satoshi Kishino, Akikazu Nomura, Zhai Suo Di, Mitsuru Sugawara, Ken Iseki, Shigeo, Kakinoki, Akira Kitabatake, and Katsumi Miyazaki: "Alpha-1-acid glycoprotein concentration and the protein binding of disopyramide in healthy subjects" J Clin Pharmacol. 35 : (impress). (1995)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1996-04-15  

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