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1994 Fiscal Year Final Research Report Summary

Search for novel peptides to increase rat platelet cAMP.

Research Project

Project/Area Number 05670623
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionMiyazaki Medical College

Principal Investigator

KITAMURA Kazuo  Miyazaki Medical College, Research associate, 医学部, 助手 (50204912)

Project Period (FY) 1993 – 1994
Keywordsadrenomedullin / PAMP / hypotensive peptide / radioimmunoassay / hypertension / circulation control
Research Abstract

Using the assay system which monitor the activity to increase rat platelet cAMP,we have discovered a novel hypotensive peptide, designated "adrenomedullin", in human pheochromocytoma extract. It has potent and long-lasting vasodilator effects in several vascular systems. In addition to adrenomedullin, another hypotensive peptide, termed "proadrenomedullin N-terminal 20 peptide" (PAMP) is found to be processed from the adrenomedullin precursor. Although initially isolated from human pheochromocytoma tissue and porcine adrenal medullae, adrenomedullin mRNA is highly expressed in several peripheral organs including cardiovascular tissues. Taken together with a significant increase in plasma immunoreactive adrenomedullin levels in patients with cardiovascular diseases, adrenomedullin is a novel factor regulating blood pressure and circulation. Futhermore, ubiquitous expression of adrenomedullin mRNA indicates its various biological functions as well as the existence of a novel circulation control system.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Kitamura Kazuo: "Adrenomedullin:a novel hypotensive peptide isolated from human pheochromocytoma." Biochem.Biophys.Res.Commun.192. 553-560 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kitamura Kazuo: "Immunoreactive adrenomedullin in human plasma." FEBS Lett.341. 28- (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kitamura Kazuo: "Cloning and characterization of cDNA encoding a precursor for human adrenomedullin." Biochem.Biophys.Res.Commun.194. 720-725 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kitamura Kazuo: "Complete amino acid sequence of porcine adrenomedullin and cloning of cDNA encoding its precursor." FEBS Letters. 338. 6-10 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kitamura Kazuo: "Identification and hypotensive activitiy of proadrenomedullin N-terminal 20 peptide(PAMP)." FEBS Letters. 351. 35-37 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kitamura Kazuo: "Adrenomedullin:Implications to hypertension research." Drugs. (in press.).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kitamura Kazuo et al.: "Adrenomedullin : a novel hypotensive peptide isolated from human pheochromocytoma." Biochem.Biophys.Res.Commum.192. 553-560 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kitamura Kazuo et al.: "Cloning and characterization of cDNA encoding a precursor for human adrenomedullin." Biochem.Biophys.Res.Commum.192. 553-560 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kitamura Kazuo et al.: "Complete amino acid sequence of porcine adrenomedullin and cloning of cDNA encoding its precursor." FEBS Letters. 338. 6-10 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kitamura Kazuo et al.: "Immunoreactive adrenomedullin in human plasma." FEBS Lett.341. 288-290 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kitamura Kazuo et al.: "Identification and hypotensive activity of proadrenomedullin N-terminal 20 peptide(PAMP)" FEBS Letters. 351. 35-37 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kitamura Kazuo et al.: "Adrenomedullin : Implications to hypertension research." Drugs. (in press). (1995)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1996-04-15  

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