1994 Fiscal Year Final Research Report Summary
The significance of the low molecular fraction of house dust mite on allergic diseases
| Project/Area Number |
05670657
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Gunma University School of Medicine |
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Principal Investigator |
MORIKAWA Akihiro Gunma University Sch.Med.Dept.of pediatrics Professor, 医学部, 教授 (40125878)
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| Co-Investigator(Kenkyū-buntansha) |
KUROUME Takayoshi Gunma University Sch.Med.Dept.of Pediatrics, 医学部, 教授 (40008280)
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| Project Period (FY) |
1993 – 1994
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| Keywords | allergic diseases / house dust mite / low molecular fraction |
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| Research Abstract |
By purification of house dust mite (Dermatophagoides farinae, Df) using gel chromatography, it revealed that low molecular weight fraction (Df-LMW) of Df contained five fractions and these fraction contain much sugar. Df-LMW under the 10Kd might be sugar rich haptenic substance and these and atopic dermatitis.
We are going to make recombinant Df-LMW using expression vector. rDf-LMW may contribute to the pathogenesis and therapy of allergic diseases.
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