1994 Fiscal Year Final Research Report Summary
Basic and Clinical Research for Hepatitis C Virus Infection with Malignant Disease in Childhood
| Project/Area Number |
05670687
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Yokohama City University |
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Principal Investigator |
IKUTA Koichiro Yokohama City University, School of Medicine, Assistant Professor, 医学部, 講師 (80159590)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUYAMA Shusuke Yokohama City University, School of Medicine, Professor, 医学部, 教授 (20045983)
SASAKI Hideki Yokohama City University, School of Medicine, Associate Professor, 医学部, 助教授 (50106316)
SUMITA Hiroko Yokohama City University, School of Medicine, Instructor, 医学部, 助手 (10254202)
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| Project Period (FY) |
1993 – 1994
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| Keywords | Malignant diseases / Hepatitis C / Liver Biopsy / IFN-therapy / RT-PCR |
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| Research Abstract |
We evaluated the efficacy of interferon (IFN) therapy for ten cases with hepatitis C virus (HCV) infection, who had completely recovered from leukemia and other malignant diseases. The transaminase level was mildly elevated in eight cases, though remained normal in two cases. The pathological findings of liver biopsy before the IFN therapy showed persistent or aggressive chronic hepatitis in all cases. In four cases, HCV-RNA was continuously undetectable in the sera over one year after the cessation of IFN therapy. The pathological findings of the liver were remarkably improved in these cases. In three cases, disappearance of HCV-RNA was transient and the transaminase level was elevated again after the IFN therapy. No correlation was observed among the liver function, pathological finding, and the response to IFN.We concluded that the IFN therapy for the HCV infected children with malignancies was effective.
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[Publications] M.Tsukaada, A.Komiyama, S.Nakazawa, M.Tsuchida, H.Nishihira, T.Shitara, M.Ohira, Y.Tsunematsu, K.Yamamoto, Y.Hoshi, K.Yamada, R.Hosoya, T.Sato, F.Bessho, I.Tsukimoto, M.Yamamoto, K.Ikuta, T.Saito, K.Nishimura, and the Tokyo Children Cancer Study Group: "Treatment of standard risk acute lymphoblastic leukemia in children with the Tokyo Children Cancer Group (TCCSG) L84-11 protocol in Japan." International Journal of Hematology. 57. 1-7 (1993)
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「研究成果報告書概要(欧文)」より
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[Publications] K.Ikuta, K.Fujioka, H.Tkahashi, H.Sumita, H.Sekiguchi, N.Hanzawa, S.Kai, Y.Kajigaya, T.Funabiki.T.Okuyama, H.Sasaki, S.Matsuyama: "Treatment and Prognosis after Late Relapse in Childhood Acute Lymphoblastic Leukemia." Jpn.J.Clin.Hematol.34. 712-717 (1993)
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「研究成果報告書概要(欧文)」より
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[Publications] H.Sasaki, K.Ikuta.T.Okuyama, T.Funabiki, Y.Kajigaya, S.Kai, H.Sekiguchi, N.Hanzawa, H.Sumita, H.Takahashi, K.Fujioka, M.Matsuda, S.Matsuyama: "The clinical course of acquired aplastic anemia in childhood ; a retrospective study" Int.J.Hematol. 60. 239-249 (1994)
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[Publications] H.Sasaki, Y.Hirabayashi, T.Ishibashi, T.Inoue, M.Matsuda, S.Kai, K.Ikuta, K.Yokoyama, T.Yokota, Y.Maruyama, S.Matsuyama: "Effects of erythropoietin, IL-3, IL-6, and LIF on a murine megakaryoblastic cell line : Growth enhancement and expression og receptor mRNAs." Leukemia Research. (in press).
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