1994 Fiscal Year Final Research Report Summary
Research on the effect of acidosis on the vascular function in the premature vessels
| Project/Area Number |
05670702
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Tokyo Women's Medical College |
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Principal Investigator |
NAKANISHI Toshio Tokyo Women's Medical College Department of Medicine Associate Professor, 医学部, 助教授 (90120013)
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| Co-Investigator(Kenkyū-buntansha) |
KAZUO Momma Tokyo Women's Medical College Department of Medicine Professor, 医学部, 教授 (80075233)
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| Project Period (FY) |
1993 – 1994
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| Keywords | Acidosis / Aorta / Mesentenc arfery / Smooth muscle / Newborn / Intracellular pH / Intracellular Ca |
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| Research Abstract |
This study investigated the effect of respiratory acidosis on intracellular pH (pH_i), intracellular calcium concentration ( [Ca] _i), and vascular contraction in the aorta and mesenteric artery of the newborn and adult rabbit. Isometric tension was measured in the isolated ring preparation. After the vascular contraction was induced with 50mM KCl, the effect of acidosis was studied. Respiratory acidosis caused transient depression followed by a recovery of contractile tension. The decrease of developed tension in the newborn was greater than that in the adult. The decrease in pHi during acidosis was similar in the two age groups. The fura-2 fluorescence ratio increased during acidosis and the increase in the newborn was was similar to that in the adult. These data suggest that the vasorelaxant effect of acidosis in the premature vessels was greater than in the mature vessels. The greater vasodilation in the newborn cannot be explained by the difference in pHi or [Ca]i responses.
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