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1994 Fiscal Year Final Research Report Summary

Studies on in vivo binding ability of anti-nuclear antibodies to epidermal cell nucleus

Research Project

Project/Area Number 05670729
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionHamamatsu Univ., School of Med., Dept.of Dermatol.

Principal Investigator

FURUKAWA Fukumi  Hamamatsu Univ., School of Med., Dept.of Dermatol., Associate Prof., 医学部, 助教授 (40156964)

Co-Investigator(Kenkyū-buntansha) TOKURA Yoshiki  Hamamatsu Univ., School of Med., Dept.of Dermatol., Assistant Prof., 医学部, 講師 (00172156)
Project Period (FY) 1993 – 1994
KeywordsMRL mouse / lupus erythematoses / anti-nuclear antibody / MCTD / Skin
Research Abstract

The mechanisms of epidermal nuclear staining (ENS) and its relation to skin lesions are still controversial and unclear. We tried to find spontaneous autoimmune prone model mice with ENS in order to better understand the pathological mechanisms. Our results are as follows ;
1.We first demonstrated the epidermal nuclear staining by direct immunofluorescence in aged MRL/Mp-+/+ mice. This positive staining was correlated with the positive nuclear staining of kidney in examined mice.
2.Spontaneous skin lesions appeared in the age-dependent manner. Light microscopy showed little lymphocytes infiltration, compared with that of SLE-prone MRL/lpr mic.
3.Epidermal nuclear staining was not correlated with macroscopic skin lesions.
4.In female aged MRL/n mice, there was the positive association between epidermal nuclear staining and anti-RNP antibodise.
These results suggested thatged MRL/n mice provide unique models for investigating the mechanisms of epidermal nuclear staining by direct immunofluorescence technique.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Furukawa,F.: "Pathogenesis of lupus dermatoses in autoimmune mice.XIX.Attempts to induce subepidermal immunoglobulin deposition in MRL/MPMp_<-+/+> mice." Arch Dematol Res. 285. 20-26 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Furukawa,F.: "Relationship between heat shock protein induction and The binding of antibodies to the extractable nuclear antigens on cultured human keratinocytes." J Invest Dermatol. 101. 191-195 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Furukawa,F.: "Susceptibility to UVB light in cultured keratinocytes of cutaneous lupus erythematosus." Dermatology. 189. 18-23 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kanauchi,H: "Effects of cyclosporin A on lupus dermatoses in autoimmune-prone MRL/MP-lpr/lpr mice." J Dermatol Treat. 5. 187-191 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kanauchi,H: "Evaluation of the Japanese-Chinese herbal medicine,Kampo,for the treatment of lupus dermatoses in autoimmune prone MRL/MP-lpr/lpr mice." J Dermatol. 21. 935-939 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Furukawa,F.: "FK506:therapeutic effects on lupus dermatoses in autoimmune-prone MRL/MP-lpr/lpr mice." Arch Dermatol Res. (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 古川 福実: "アレルギー産業環境からのアプローチ" 金原出版, 368 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 古川 福実: "皮膚科における漢方治療の現況" 医学書院, 136 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Furukawa, F.et al.: "Pathogenesis of lupus dermatoses in autoimmune mice. XIX.Attempts to induce subepidermal immunoglobulin deposition in MRL/Mp-+/+ mice." Arch Dermatol Res.285. 20-26 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Furukawa, F.et al.: "Relationship between heat shock protein induction and the binding of antibodies to the extractable nuclear antigens on cultured human keratinocytes." J Invest Dermatol.101. 191-195 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Furukawa, F.et al.: "Susceptibility to UVB light in cultured keratinocytes of cutaneous lupus erythematosus." Dermatology. 189(Suppl 1). 18-23 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kanauchi, H.et al.: "Effects of cyclosporin A on lupus dermatoses in autoimmune-prone MRL/Mp-lpr/lpr mice." J Dermatol Treat. 5. 187-191 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kanauchi, H.et al.: "Evaluation of the Japanese-Chinese herbal medicine, Kampo, for the treatment of lupus dermatoses in autoimmune prone MRL/Mp-lpr/lpr mice." J Dermatol. 21. 935-939 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Furukawa, F.et al.: "FK506 : therapeutic effects on lupus dermatoses in autoimmune-prone MRL/Mp-lpr/lpr mice." Arch Dermatol Res. (in press).

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1996-04-15  

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