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1995 Fiscal Year Final Research Report Summary

Human papillomavirus type-specific cytopathogenic effect

Research Project

Project/Area Number 05670734
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionKUMAMOTO UNIVERSITY

Principal Investigator

EGAWA Kiyofumi  Kumamto University School of Medicine, Instructor, 医学部, 講師 (50183215)

Co-Investigator(Kenkyū-buntansha) ONO Tomomichi  Kumamto University School of Medicine, Professor, 医学部, 教授 (10040586)
Project Period (FY) 1993 – 1995
KeywordsHPV / Cytopathogenic effect / Intracytoplasmic inclusion body / HPV 60 / HPV 63 / HPV 65 / Epidermoid cyst / Eccrine duct
Research Abstract

(1) We revealed that two new types of intracytoplasmic inclusion bodies (ICBs) were associated with distinct clinical features, and the presence of DNA of distinct types of human papillomaviruses. HPV 1 DNA sequences were detected in all the lesions with well-known granular ICBs. Punctate keratotic lesions with filamentous ICBs were associated with HPV 63, which was newly cloned from such a lesion. Pigmented warts with homogeneous ICBs contained one of the related HPVs, i.e., HPV 4, HPV 60 or a novel type of HPV,HPV 65. Based on these associations, a classification of inclusion warts is proposed.
(2) Although epidermoid cysts of the palms and soles have long been assumed to develop following implantation of an epidermal fragments as a result of a penetrating injury, the pathomechanism is still controversial. Clinical, histological, immunohistochemical and molesular biological studies were performed on 119 epidermoid cysts of palmoplantar location, inorder to examine the role of the eccrine ducts, and human papillomavirus (HPV) , in the pathogenesis of this disorder.
Either ductal structures of carcinoembryonic antigen expression were noted in a total of 73 cases (61%). Papillomavirus common antigens were detected in 36 cases (30%) showing one or more of the three distinct histological features, i.e., intracytoplasmic inclusion bodies (ICBs) , vacuolar structres and parakeratosis in the cyst cavity. On the basis of our results, we propose that epidermoid cysts in the palmoplantar regions may develop from eccrine ducts, and that HPV may play a role in their pathogenesis.

  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Egawa K.: "Varied clinical morphology of HPV induced warts, depending on anafomical factors." British Journal of Dermatology. 128. 271-276 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Egawa K.: "Two novel types of human papillomavirus, HPV63 and HPV65: Comparisons of their clinical and histoligical features and DNA sequences to other HPV types." Virology. 194. 789-799 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Egawa K.: "Double infection with HPV 1 and HPV 63 in single cells of a lesion displaying only an HPV 63 -induced cytopathogenic effect" Laboratory Investigation. 69. 583-588 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Inaba Y.: "Demonstration of HPV 1 DNA in a wart with bowenoid histologic changes." American Journal of Dermatopathology. 15. 172-175 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Egawa K.: "Inverted plantar wart." Archives of Dermatology. 129. 385-386 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Egawa K.: "New types of HPVs and intracytoplasmic inclusion bodies: a classification of inclusion warts according to clinical features, histology and associated HPV types." British Journal of Dermatology. 130. 158-166 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Egawa K.: "Muitiple plantar epidermoid cysts harboring carcinoembryonic antigen and HPV DNA sequences." Journal of American Academy of Dermatology. 30. 494-496 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Egawa K.: "Defection of HPVs and eccrine ducts in palmoplantor epidermoid cysts." British Journal of Dermatology. 132. 533-542 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Egawa K.: "Multiple giant molluscum contagiosa with cyst formation." American Journal of Dermatopathology. 17. 414-416 (1995)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Honda Y.: "Sweat duct milia-immunohistochemical and three-dimensional reconstruction analysis of structure." Archives of Dermatologica Research. 288(in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Egawa K.: "CEA, and related antigens expressed on keratinocytes in inflammatory cutaneous diseases." British Journal of Dermatology.134(in press). (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Egawa K.: "Cutaneous warts: Recent advances." Japan Journal of Dermatology. 106. 91-99 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Egawa K,Inaba Y,Yoshimura K,Ono T.: "Varied clinical morphology of HPV 1induced warts, depending on anatomical factors." Br J Dermatol. 128. 271-276 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] EgawaK,Delius H,Matsukura T,Kawashima M,de Villiers EM.: "Two novel types of human papillomavirus, HPV 63 and HPV 65 : Comparisons of their clinical and histological features and DNA sequences to other HPV types." Virology. 194. 789-799 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Egawa K,Shibasaki Y,de Villiers EM.: "Double infection with HPV 1 and HPV 63 in single cells of a lesion displaying only an HPV 63-induced cytopathogenic effect." Lab Invest. 69. 583-588 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Inaba Y,Egawa K,Yoshimura K,Ono T.: "Demonstration of HPV 1 DNA in a wart with bowenoid histologic changes." Am J Dermatopathol. 15. 172-175 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Egawa K,Hayashibara T,Ono T.: "Inverted plantar wart." Arch Dermatol. 129. 385-386 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Egawa K.: "New types of HPVs and intracytoplasmic inclusion bodies : a classification of inclusion warts according to clinical features, histology and associated HPV types." Br J Dermatol. 130. 158-166 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Egawa K,Honda Y,Inaba Y,Kojo Y,Ono T,de Villiers EM.: "Multiple plantar epidermoid cysts harboring carcinoembryonic antigen and HPV DNA sequences." J Am Acad Dermatol. 30. 494-496 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Egawa K,Honda Y,Inaba Y,Ono T,de Villiers EM.: "Detection of HPVa and eccrine ducts in palmoplantar epidermoid cysts." Br J Dermatol. 132. 533-542 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Egawa K,Honda Y,Ono T.: "Multiple giant molluscum contagiosa with cyst formation." Am J Dermatopathol. 17. 414-416 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Honda Y,Egawa K,Baba Y,Ono T.: "Sweat duct milia-immunohistochemical and three-dimensional reconstrution analysis of structure." Arch Dermatol Res. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Egawa K,Honda Y,Kuroki Ma, Inaba Y,Ono T.: "CEA,and related antigens expressed on keratinocytes in inflammatory cutaneous diseases." Br J Dermatol. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Egawa K.: "Cutaneous warts : Recent advances." Jpn J Dermatol. 106. 91-99 (1996)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1997-03-04  

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